中药单体调控“细胞自噬”防治皮瓣坏死  

Traditional Chinese medicine monomer in the prevention and treatment of flap necrosis by regulating“autophagy”

作　　者：马岁录 何志军[2] 刘涛 李岩[2] 何元旭 何波 王威威 魏晓涛 Ma Suilu;He Zhijun;Liu Tao;Li Yan;He Yuanxu;He Bo;Wang Weiwei;Wei Xiaotao(Clinical College of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730030,Gansu Province,China;Department of Foot and Ankle Orthopedics,Gansu Provincial Hospital of TCM,Lanzhou 730050,Gansu Province,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃省兰州市730030 [2]甘肃省中医院足踝骨科,甘肃省兰州市730050

出　　处：《中国组织工程研究》2024年第1期153-158,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81660802),项目负责人:何志军;甘肃省中医药管理局重点课题(GZKZ-2020-2),项目负责人:何志军;甘肃省重点研发计划项目(21YF5FA021),项目负责人:何志军;甘肃省青年科技基金计划项目(21JR11RA211),项目负责人:刘涛;甘肃省人才创新创业专项(2019-RC-63),项目负责人:何志军。

摘　　要：背景:近年来,有研究发现部分中药单体通过激活细胞自噬可缓解皮瓣氧化应激与细胞凋亡,促进皮瓣血管再生,防治皮瓣坏死。目的:综述中药单体调控细胞自噬防治皮瓣坏死的研究进展。方法:分别以“中药、细胞自噬、皮瓣”与“Traditional Chinese Medicine (TCM),Autophagy,Skin flaps”为中英文检索词,由第一作者检索2010年1月至2022年10月发表在中国知网与PubMed数据库的相关文献,文献初筛共检索到相关文献196篇,以纳入和排除标准进行筛选,通过阅读文献标题与摘要进行质量评估,最终归纳整理55篇文献进行综述。结果与结论:(1)细胞自噬的调控是由AMPK/mTOR和PI3K/AKT等信号通路介导的,激活细胞自噬可缓解皮瓣氧化应激与细胞凋亡,促进皮瓣血管再生,防治皮瓣坏死。(2)中药单体中的萜类化合物(桦木酸、穿心莲内酯、三七三萜和梓醇)、酚类化合物(白藜芦醇、姜黄素和天麻素)、酚酸类化合物(丹酚酸B)及类固醇类化合物(拟人参皂甙F11)可通过调控相关信号通路激活细胞自噬来缓解皮瓣氧化应激与细胞凋亡,促进皮瓣血管再生,促皮瓣存活。(3)文章通过总结中药单体调控细胞自噬防治皮瓣坏死的研究进展,为临床上中药防治皮瓣坏死、促进皮瓣愈合提供参考与理论依据。BACKGROUND:In recent years,it has been found that some traditional Chinese medicine monomers can alleviate oxidative stress and apoptosis of the skin flap,promote vascular regeneration of the skin flap and prevent skin flap necrosis by activating autophagy.OBJECTIVE:To review the research progress of traditional Chinese medicine monomer regulating autophagy in preventing flap necrosis.METHODS:The Chinese and English key words were“traditional Chinese medicine(TCM),autophagy,skin flaps”.The first author searched the relevant articles published in CNKI and PubMed databases from January 2010 to October 2022.A total of 196 articles were retrieved in the preliminary screening and then screened according to the inclusion and exclusion criteria.The quality assessment was conducted by reading the literature titles and abstracts.Finally,55 articles were summarized.RESULTS AND CONCLUSION:(1)The regulation of autophagy is mediated by AMPK/mTOR,PI3K/AKT and other signaling pathways.Activation of autophagy can alleviate the oxidative stress and apoptosis of the flap,promote the regeneration of blood vessels in the flap,and prevent flap necrosis.(2)Terpenoids(Betulinic acid,Andrographolide,Notoginseng Triterpenes,Catalpa),phenolic compounds(Resveratrol,Curcumin,Gastrodin),phenolic acids(Salvianolic acid B)and steroid compounds(Pseudoginsenoside F11)in traditional Chinese medicine monomers can alleviate oxidative stress and apoptosis of skin flap by regulating related signaling pathways to activate autophagy,promote skin flap angiogenesis and promote skin flap survival.(3)Studying the research progress of traditional Chinese medicine monomer to prevent flap necrosis by regulating autophagy can provide a reference and theoretical basis for traditional Chinese medicine to prevent flap necrosis and promote flap healing in the clinic.

关 键 词：皮瓣 细胞自噬 氧化应激 细胞凋亡 血管再生 中药单体 AMP活化蛋白激酶(AMPK)/雷帕霉素靶点(mTOR) 磷脂肌醇激酶(PI3K)/蛋白激酶B(AKT) 研究进展 

分 类 号：R453[医药卫生—治疗学] R363[医药卫生—临床医学] R285