类固醇激素合成急性调节蛋白对生殖调控作用的研究进展  

Progress on Steroidogenic Acute Regulatory Protein on Reproductive Regulation

作　　者：曾思雨 程蕊娈 王重 陈鸿 陈树林[1] ZENG Si-yu;ZHANG Cong-sheng;WANG Chong;CHEN Hong;CHEN Shu-lin(College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi,712100,China)

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100

出　　处：《动物医学进展》2023年第7期97-101,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(32172811,32002242);陕西省科技计划项目(2020QFY10-04);大学生创新创业训练计划项目(S202210712527)。

摘　　要：所有类固醇激素的合成均始于胞内胆固醇,类固醇激素合成急性调节蛋白(StAR)专一性地负责将底物胆固醇从线粒体外膜转运至内膜,该过程是类固醇激素合成的限速步骤。StAR在不同物种中具有高度的保守性,其表达主要分布于肾上腺、卵巢及睾丸组织。StAR基因的表达对动物机体生殖过程存在直接或间接影响,表达异常会导致生殖内分泌功能紊乱,影响胚胎发育及精子发生。论文探讨了StAR的基本结构特点及表达分布特征,基于StAR对胆固醇转运的作用机制,综述了StAR对动物和人类生殖内分泌的调控作用,为StAR在生殖应用方面的深入研究提供理论参考。The synthesis of all steroid hormones begins with intracellular cholesterol,and the steroidogenic acute regulatory protein(StAR)is specifically responsible for transporting the substrate cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane,which is the rate-limiting step in steroid hormone synthesis.StAR is highly conserved in different species,and its expression is mainly distributed in adrenal gland,ovary and testis.The expression of StAR gene has both direct and indirect effects on the reproductive process of the body.Abnormal expression of StAR gene can lead to the disorder of reproductive endocrine function and affect embryo development and spermatogenesis.In this paper,the basic structure characteristics and expression distribution characteristics of StAR were discussed.Based on the mechanism of StAR on cholesterol transport,the regulatory effects of StAR on animal and human reproductive endocrinology were reviewed,so as to provide theoretical reference for further research of StAR in reproductive application.

关 键 词：类固醇激素合成急性调节蛋白 类固醇激素 生殖调控 

分 类 号：S852.21[农业科学—基础兽医学]