皮内针对缓解肿瘤患者化疗相关性恶心呕吐症状的Meta分析  

A Meta-analysis of randomized controlled trial of intradermal needle in relieving symptoms of chemotherapy related nausea and vomiting in oncology patients

作　　者：张敬 徐京巾 郭红[2] 李野 唐玲[3] ZHANG Jing;XU Jingjin;GUO Hong;LI Ye;TANG Ling(Department of Nursing,Handan Central Hospital,Handan,Hebei,056000;School of Nursing Beijing University of Chinese Medicine,Beijing,100029;Department of Nursing,Dongfang Hospital Beijing University of Chinese Medicine,Beijing,100078)

机构地区：[1]河北省邯郸市中心医院护理部,河北邯郸056000 [2]北京中医药大学护理学院,北京100029 [3]北京中医药大学东方医院护理部,北京100078

出　　处：《中西医结合护理》2023年第5期17-24,共8页Chinese Journal of Integrative Nursing

摘　　要：目的系统评价皮内针对缓解癌症患者化疗引起恶心、呕吐(CINV)的临床疗效。方法通过计算机检索PubMed、Embase、the Cochrane Central Register of Controlled Trials(CENTAL)、Web of Science、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普(VIP)和万方数据库(Wanfang Data),检索时间均为建库至2022年11月,收集揿针埋针缓解癌症患者CINV的随机对照研究。经过文献筛选、资料提取、质量与偏倚风险评估后,采用RevMan5.4.1软件进行Meta分析。结果最终纳入9篇文献,涉及癌症化疗患者797例。Meta分析的结果显示,在常规止吐治疗的基础上加用皮内针治疗能有效缓解急性CINV总有效率[RR=1.27,95%CI(1.09,1.47),P=0.003]、缓解延迟性CINV总有效率[RR=1.23,95%CI(1.07,1.41),P=0.005],降低CINV严重程度[RR=1.42,95%CI(1.02,1.79),P<0.001]、延长首次呕吐的时间[MD=5.88,95%CI(5.70,6.05),P<0.001]、提高恶心呕吐生活功能指数(FLIE)评分[MD=9.26,95%CI(4.63,13.88),P<0.001],观察组疗效优于对照组,差异具有统计学意义。结论皮内针缓解恶性肿瘤化疗后呕吐疗效显著,但还需要更多的研究数据支持。Objective To analyze the efficacy of using intradermal needle in alleviating nausea and vomiting caused by chemotherapy in cancer patients through systematic evaluation.Methods Information on randomized controlled trial(RCT)for intradermal needle in alleviating nausea and vomiting caused by chemotherapy in cancer patients were retrieved in PubMed,EMBASE,the Cochrane Central Register of Controlled Trials(CENTAL),Web of Sciences,China National Knowledge Infrastructure(CNKI),China Biology Medicine(CBM),VIP,and Wanfang Data,with the retrieval time limit from the establishment of databases until November 2022.After literature screening,data extraction,quality and bias risk assessment,RevMan 5.4.1 software was used for meta-analysis.Results Nine articles were included,involving 797 cancer patients receiving che⁃motherapy.The results of meta-analysis showed that on the basis of conventional antiemetic treatment,the treatment of pressing needle and embedding needle could effectively alleviate the total effective rate of acute CINV[RR=1.27,95%CI(1.09,1.47),P=0.003],the total effective rate of delayed CINV[RR=1.23,95%CI(1.07,1.41),P=0.005],reduce the severity of CINV[RR=1.42,95%CI(1.02,1.79),P<0.001],and prolong the time of first vomiting[MD=5.88,95%CI(5.70,6.05),P<0.001]The FLIE score of nausea and vomiting quality of life was improved[MD=9.26,95%CI(4.63,13.88),P<0.001].The effect of the observation group was better than that of the control group,and the difference was statistically significant.Conclusion The effectiveness of intradermal needle in relieving vomiting after chemotherapy for malignant tumors is significant,but more research data are needed to support it.

关 键 词：皮内针 癌症 化疗 恶心呕吐 系统评价 

分 类 号：R473.73[医药卫生—护理学]