对氨基水杨酸、异烟肼联合左氧氟沙星、丙硫异烟胺对复治结核患者的治疗效果分析  

Analysis of Therapeutic Effect of Aminosalicylic Acid Isoniazid Combined with Levofloxacin and Protioisoniacamide in Patients with Retreated Tuberculosis

作　　者：葛雨平 李明辉 Ge Yu-ping;Li Ming-hui(Department of Infection,Yangzhou Jiangdu District Third People's Hospital,Yangzhou 225200,Jiangsu Province,China)

机构地区：[1]扬州市江都区第三人民医院感染科,江苏扬州225200

出　　处：《中外医药研究》2023年第2期66-68,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析对氨基水杨酸(PAS)、异烟肼(INH)联合左氧氟沙星(Lfx)、丙硫异烟胺(Pto)对复治结核患者的治疗效果。方法:选取2018年4月—2019年4月扬州市江都区第三人民医院感染科收治的结核病患者80例作为研究对象,根据随机数字表法分为参照组和研究组,各40例。参照组给予利福平联合PAS治疗,研究组给予PAS、INH联合Lfx、Pto治疗。比较两组患者治疗效果、不良反应发生率、空洞闭合率、18个月末痰菌转阴率和血清炎性因子水平。结果:研究组治疗总有效率高于参照组,差异有统计学意义(P=0.003)。研究组不良反应发生率低于参照组,差异有统计学意义(P=0.013)。研究组空洞闭合率、18个月末痰菌转阴率均高于参照组,差异有统计学意义(P<0.05)。治疗后,两组患者白细胞介素8(IL-8)、肿瘤坏死因子-α(TNF-α)和高敏C反应蛋白(hs-CRP)水平均下降,差异有统计学意义(P<0.05);研究组IL-8、TNF-α、hs-CRP水平低于参照组,差异有统计学意义(P<0.001)。结论:PAS、INH联合Lfx、Pto对复治结核患者的临床治疗效果显著,可促进空洞缩小与闭合,降低炎性反应,清除细菌,促进痰菌转阴,具有较高的安全性。Objective:To analyze the therapeutic effect of P-aminosalicyic acid(PAS)、Isoniazi(INH)combined with levofloxacin(Lfx)and protioisoniacamide(Pto)on patients with retreated tuberculosis.Methods:Eighty tuberculosis patients admitted to the Department of Infection of Jiangdu Third People's Hospital from April 2018 to April 2019 were selected as the research objects and divided into the control group and the study group according to the random number table method,with forty cases in each group.The control group was given rifampicin combined with PAS,and the study group was given PAS、INH combined with Lfx and Pto.The therapeutic effect,incidence of adverse reactions,cavity closure rate,sputum negative conversion rate at the end of 18 months and serum inflammatory factors were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P=0.003).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P=0.013).The cavity closure rate and sputum negative conversion rate at the end of 18 months in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-8(IL-8),tumor necrosis factor(TNF-α)and high-sensitive C-reactive protein(hs-CRP)in 2 groups were decreased,and the difference was statistically significant(P<0.05);The levels of IL-8,TNF-αand hs-CRP in the study group were lower than those in the control group,with statistical significance(P<0.001).Conclusion:PAS combined with Lfx and Pto has significant clinical therapeutic effect on patients with retreated tuberculosis,which can promote cavity narrowing and closure,reduce inflammatory response,remove bacteria,and promote sputum to turn negative,with high safety.

关 键 词：对氨基水杨酸 异烟肼 左氧氟沙星 丙硫异烟胺 复治结核 不良反应 

分 类 号：R52[医药卫生—内科学]