糖化血清白蛋白联合糖化血红蛋白检测在糖尿病肾病患者中的应用价值分析  

Analysis of the Value of Glycated Serum Albumin Combined with Glycated Hemoglobin Test in Patients with Diabetic Nephropathy

作　　者：宋智心 郝银山 殷文静 贾利敏[2] 高玮 Song Zhi-xin;Hao Yin-shan;Yin Wen-jing;Jia Li-min;Gao Wei(Beijing Mentougou District Hospital of Traditional Chinese Medicine,Beijing 102300,China;Beijing Fangshan District Liangxiang Hospital,Beijing 102401,China)

机构地区：[1]北京市门头沟区中医医院,北京102300 [2]北京市房山区良乡医院,北京102401

出　　处：《中外医药研究》2023年第2期145-147,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：国家重点研发计划“老年病相关生化诊断试剂量值溯源及质量评价研究”(编号:2019YFF0216502)。

摘　　要：目的:分析糖化血清白蛋白(GA)联合糖化血红蛋白(HbA1c)检测在糖尿病肾病(DN)患者中的应用价值。方法:选取2019年5月—2021年4月北京市房山区良乡医院和门头沟区中医医院内分泌科住院的糖尿病患者256例为观察对象,按疾病诊断分为DN组127例和非DN组129例;选取同期本院健康体检人群99例为健康对照组。测定并分析HbA1c、GA,计算GA∶HbA1c,采用多因素回归分析评价DN的预测因素。结果:DN组尿素氮、肌酐、尿酸、低密度脂蛋白胆固醇高于健康对照组,差异有统计学意义(P<0.05)。DN组GA和GA∶HbA1c高于非DN组,差异有统计学意义(P<0.05)。GA和GA∶HbA1c分别与DN患者的年龄、血糖、有无视网膜病变进行多因素相关分析。GA和GA∶HbA1c预测DN比值分别为2.61和1.96,95%CI分别为1.18,3.89和1.01,2.26,差异有统计学意义(P<0.05)。结论:GA联合HbA1c检测对DN的诊断有一定的应用价值。Objective:To analyze the value of glycated serum albumin(GA)combined with glycated hemoglobin(HbA1c)testing in patients with diabetic nephropathy(DN).Methods:Two hundred and fifty-six diabetic patients hospitalized in the Department of Endocrinology,Beijing Fangshan District Liangxiang Hospital and Mentougou District Hospital of Traditional Chinese Medicine from May 2019 to April 2021 were selected as observation subjects.According to the disease diagnosis,one hundred and twenty-seven cases were divided into DN group and non-DN group of one hundred and twenty-nine cases,and ninety-nine cases were selected as the healthy control group in the same period of healthy physical examination in the hospital.HbA1c and GA were measured and analyzed,GA:HbA1c was calculated,and multi-factor regression analysis was used to evaluate the predictors of DN.Results:Urea nitrogen,creatinine,uric acid and low-density lipoprotein cholesterol were higher in the DN group than in the healthy control group,and the differences were statistically significant(P<0.05).GA and GA:HbA1cwere higher in the DN group than in the non-DN group,and the difference was statistically significant(P<0.05).GA and GA:HbA1c were multi-factor correlated with age,blood glucose,and presence of retinopathy in patients with DN,respectively.GA and GA:HbA1c predicted DN ratios of 2.61 and 1.96,respectively,with 95%CI of 1.18,3.89 and 1.01,2.26,respectively,and the differences were statistically significant(P<0.05).Conclusion:GA combined with HbA1ctest has some application value for the diagnosis of DN.

关 键 词：糖化血清白蛋白 糖化血红蛋白 糖尿病肾病 贫血 

分 类 号：R58[医药卫生—内分泌]