赖氨肌醇维B 12辅助营养支持及健康指导治疗儿童营养不良的临床疗效  

Clinical Efficacy of Lysine Inositol Vitamin B 12 as Auxiliary Nutritional Support and Health Guidance in the Treatment of Malnutrition in Children

作　　者：陈蓓蕾[1] 赵晓丹 CHEN Bei-lei;ZHAO Xiao-dan(Department of Pediatrics,Baoji Central Hospital,Baoji Shaanxi 721400)

机构地区：[1]宝鸡市中心医院儿科,陕西宝鸡721400

出　　处：《医学临床研究》2023年第5期686-689,共4页Journal of Clinical Research

摘　　要：【目的】赖氨肌醇维B 12辅助营养支持及健康指导治疗儿童营养不良的临床疗效。【方法】选取2017年2月至2021年3月本院收治的96例儿童营养不良患儿,根据治疗方法的不同将其分为观察组和对照组,每组48例。对照组给予常规营养支持及健康指导,观察组在对照组的基础上给予赖氨肌醇维B 12口服溶液治疗,两组均治疗3个月。比较两组的临床疗效及治疗前后血清学指标[血红蛋白(Hb)、白蛋白(ALB)、总蛋白(TP)]、微量元素(钙、铁、锌)。记录观察组患儿不良反应发生情况。【结果】观察组总有效率为97.92%(47/48),高于对照组的83.33%(40/48),差异有统计学意义(P=0.036)。治疗后,两组Hb、ALB、TP高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组患儿钙、铁、锌水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组发生1例腹泻、2例恶心,不良反应发生率为6.25%(3/48),程度较轻,未作特殊处理自行好转。【结论】赖氨肌醇维B 12口服溶液能有效治疗儿童营养不良,有助于促进钙、铁、锌等微量元素的吸收,值得临床借鉴。【Objective】To study the clinical efficacy of lysine inositol vitamin B 12 as auxiliary nutritional support and health guidance in the treatment of malnutrition in children.【Method】A total of 96 children with malnutrition admitted to our hospital from February 2017 to March 2021 were selected and divided into an observation group and a control group based on different treatment methods,with 48 cases in each group.The control group received routine nutritional support and health guidance,while the observation group received treatment with lysine inositol vitamin B 12 oral solution on the basis of the control group.Both groups were treated for three months.The clinical efficacy and serum indicators[hemoglobin(Hb),albumin(ALB),total protein(TP)],and trace elements(calcium,iron,zinc)before and after treatment were compared between the two groups.The occurrence of adverse reactions in the observation group was recorded.【Result】The total effective rate of the observation group was 97.92%(47/48),which was higher than 83.33%(40/48)of the control group,and the difference was statistically significant(P=0.036).After treatment,the Hb,ALB,and TP of the two groups of children were higher than those before treatment,and the observation group was higher than the control group,with a statistically significant difference(P<0.05);The levels of calcium,iron,and zinc in both groups of children were higher than those before treatment,and the observation group was higher than the control group,with a statistically significant difference(P<0.05).The observation group experienced 1 case of diarrhea and 2 cases of nausea,with an adverse reaction rate of 6.25%(3/48),which was mild and improved without special treatment.【Conclusion】L-Lysine Inositol Vitamin B 12 oral solution can effectively treat malnutrition in children and promote the absorption of trace elements such as calcium,iron,and zinc,which is worthy of clinical reference.

关 键 词：儿童营养障碍/药物疗法 营养支持 治疗结果 

分 类 号：R725.91[医药卫生—儿科]