艾司洛尔联合胺碘酮对急性心肌梗死合并快速型心律失常患者心肌标记物及心电图指标的影响  

Effects of Esmolol Combined with Amiodarone on Myocardial Markers and Electrocardiogram in Patients with Acute Myocardial Infarction Complicated with Tachyarrhythmia

作　　者：孙琰 张春园 杜宗雷[1] SUN Yan;ZHANG Chunyuan;DU Zonglei(Department of Cardiology,Zoucheng People's Hospital,Jining,Shandong Province,273500 China)

机构地区：[1]邹城市人民医院心内科,山东济宁273500

出　　处：《中外医疗》2023年第14期102-106,共5页China & Foreign Medical Treatment

摘　　要：目的探讨艾司洛尔联合胺碘酮治疗急性心肌梗死(acute myocardial infarction,AMI)合并快速型心律失常的临床疗效及安全性。方法方便选取2019年10月—2021年10月邹城市人民医院收治的118例AMI合并快速型心律失常患者,随机分为两组,各59例。对照组用胺碘酮治疗,观察组加用艾司洛尔治疗,持续治疗7 d。比较两组治疗情况,并记录不良反应发生情况。结果观察组总有效率96.61%较对照组84.75%高,差异有统计学意义(χ^(2)=4.913,P<0.05)。治疗后观察组肌酸激酶同工酶(CK-MB)、超敏肌钙蛋白(hs-TnT)水平以及舒张压、收缩压、心率、左室舒张末内径(LVEDD)低于对照组,PR间期长于对照组,QT间期短于对照组,左室射血分数(LVEF)、心输出量(CO)高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论艾司洛尔联合胺碘酮可提高AMI合并快速型心律失常的治疗效果,降低患者CK-MB、hs-TnT水平,纠正心电图指标异常,加快血压、心率复常,促进心功能恢复,安全可靠。Objective To investigate the clinical efficacy and safety of esmolol combined with amiodarone in the treatment of acute myocardial infarction(AMI)with tachyarrhythmia.Methods A total of 118 patients with AMI complicated with tachyarrhythmia admitted to Zoucheng People's Hospital from October 2019 to October 2021 were conveniently selected and randomly divided into two groups with 59 cases in each group.The control group was treated with amiodarone,and the observation group was treated with esmolol for 7 days.The treatment situation of the two groups was compared,and the occurrence of adverse reactions was recorded.Results The total effective rate of 96.61%in the observation group was higher than 84.75%in the control group,and the difference was statistically significant(χ^(2)=4.913,P<0.05).After treatment,creatine kinase-MB(CK-MB),high-sensitivity troponin(hs-TnT)levels,diastolic blood pressure,systolic blood pressure,heart rate and left ventricular end-diastolic diameter(LVEDD)in the observation group were lower than those in the control group,the PR interval was longer than that of the control group,while the QT interval was shorter,the left ventricular ejection fraction(LVEF)and cardiac output(CO)were higher than those of the control group,and the difference was statistically significant(P<0.05).There were no statistically significant difference in adverse reactions rate in both groups(P>0.05).Conclusion Esmolol combined with amiodarone can improve the therapeutic effect of AMI complicated with tachyarrhythmia,reduce the level of CK-MB and hs-TnT in patients,correct abnormal ECG indicators,accelerate the recovery of blood pressure and heart rate,and promote the recovery of cardiac function,which is safe and reliable.

关 键 词：急性心肌梗死 快速型心律失常 艾司洛尔 胺碘酮 心肌标记物 安全性 

分 类 号：R542.2[医药卫生—心血管疾病]