1,2,4,5-四取代咪唑的合成  

Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles

作　　者：李艳春[1] 张鹏会[1] Li Yanchun;Zhang Penghui(College of Petroleum and Chemical Engineering,Longdong University,Qingyang,China)

机构地区：[1]陇东学院石油化工程学院,甘肃庆阳

出　　处：《科学技术创新》2023年第15期58-61,共4页Scientific and Technological Innovation

基　　金：甘肃省自然科学基金(21JR1RM335);庆阳市自然科学基金(QY2021A-F009);甘肃省化学工程与技术重点学科建设项目(GSACKS20130113);庆阳市青年科技基金(QY-STK-2022A-014);陇东学院青年科技创新项目(XYZK2111)资助。

摘　　要：无溶剂条件下,5-磺基水杨酸有效催化苯偶姻、醛、醋酸铵和伯胺发生一锅四组分缩合反应,高产率合成一系列1,2,4,5-四取代咪唑化合物。优化了影响反应的各个因素,结果表明120℃无溶剂条件下大各类伯胺和多数芳香醛均能良好地发生反应合成相应化合物,产率高达61%~90%。对产物结构进行了^(1)H NMR和^(13)C NMR表征。此法具有反应时间短、操作简单,环保友好等优点。A water-soluble Br?nsted acid,5-sulfosalicylic acid,efficiently catalyzed the direct four-component condensation reactions of aldehydes,benzyl,ammonium acetate and primary amine under free solvent.a series of tetrasubstituted imidazoles were presented.The reaction conditions and the effects of substituents were discussed in detail.The results showed that a variety of primary amine and most of the aldehydes with different substituents could all react well with excellent yields of 57%-90%in solventless medium at 120℃.The structures of the products were characterized by ^(1)H NMR and ^(13)C NMR spectra.This method provides a good pathway for the synthesis of trisubstituted imidazoles derivatives in the terms of excellent yields,shorts rection,mild condition and simple work-up procedure.

关 键 词：5-磺基水杨酸 咪唑 无溶剂 合成 药物中间体 

分 类 号：TQ630[化学工程—精细化工]