中医药改善肝动脉栓塞综合征的用药规律分析和网络药理学研究  

Study on the Medication Laws and Network Pharmacology of Traditional Chinese Medicine in Improving Post-embolization Syndrome

作　　者：万子璇 李娜[1] 卢冬彦[2] 叶小卫[2] WAN Zi-xuan;LI Na;LU Dong-yan;YE Xiao-wei(The First Clinical Medicine School,Guangzhou University of Chinese Medicine,Guangzhou 510000 Guangdong,China;Tumor Department,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510000 Guangdong,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510000 [2]广州中医药大学第一附属医院肿瘤科,广东广州510000

出　　处：《中医肿瘤学杂志》2023年第3期57-64,共8页Journal of Oncology in Chinese Medicine

基　　金：科技创新战略研究专项(编号:ZLY202019);2023年科技创新项目(编号:2023YDZ11)。

摘　　要：目的 采用中医传承计算平台挖掘中药复方改善肝动脉栓塞综合征的用药规律,通过网络药理学研究其初步作用机制并运用分子对接进行验证。方法 以“中医”“中药”“TACE术后”“肝动脉栓塞术后”“化疗栓塞综合征”为主题词,检索相关临床研究文献,筛选出其中的中药复方,应用中医传承计算平台3.0版本对复方数据进行频次统计、药物聚类及关联规则分析,并对通过聚类分析挖掘出的中药组合进行网络药理学分析,运用分子对接进行验证。结果 共检索筛选出目标文献105篇,药物功效以补虚类、清热类为主,中药四气分布主要在寒、温、平性,五味以苦、甘居多;归经以脾、肺、肝为主。通过网络药理学分析并筛选出药物主要活性成分为山奈酚、槲皮素、β-谷甾醇、黄芩素,主要通过AKT1、IL6、TNF、IL1B靶点作用于IL-17、肿瘤坏死因子、HIF-1信号通路等,分子对接显示关键活性成分靶点结合活性良好。结论 治疗原发性肝癌肝动脉栓塞综合征的复方药物以扶正补脾为主要功效,用药及配伍以疏肝理气、清热化痰、活血化瘀、补气养阴,并通过多成分、多靶点、多通路发挥改善肝动脉栓塞综合征的作用。Objective To explore the medication laws and compatibility rules of Chinese medicine in the treatment of post-embolization Syndrome(PES)based on the Traditional Chinese Medicine Inheritance Computing Platform System,and to investigate its initial therapeutic mechanism through the network pharmacology and to verify it by molecular docking technique.Methods With“traditional Chinese medicine”,“Chinese medicine”,“post TACE”,“post-embolization syndrome”and “post-chemotherapy embolization syndrome”as the keywords,the clinical research literature of Chinese medicine for oral administration in the treatment of post-embolization Syndrome was retrieved and summarized.The data on Chinese medicine compound prescriptions were extracted and collected.The frequency statistics,drug clustering and association rule analysis of Chinese medicine were carried out.Network pharmacological analysis was performed for the herbal groups obtained by cluster analysis,and the results were verified molecular docking.Results A total of 105 articles were obtained.The medicines mainly had the actions of supplementing deficiency and clearing heat.The nature of the drugs was characterized by being cold,warm,mild,and their flavors characterized by being bitter and sweet.The drugs had the meridian tropism of spleen,lung,and liver.Network pharmacological analysis showed that the main active ingredients of the drugs were quercetin,kaempferol,beta-sitosterol,and baicalein,and the herbs had the AKT1,IL6,TNF,and IL1B targets through IL-17,tumor necrosis factor pathway and HIF-1 signaling pathway.Meanwhile,molecular docking results showed that binding activity of key active ingredient targets was strong.Conclusion Compound Chinese medicines for treating post-embolization syndrome of primary liver cancer mainly have the actions of supporting healthy Qi and invigorating spleen,and the compatibility is characterized by herbs for soothing liver Qi,clearing heat and resolving phlegm,promoting blood circulation and removing blood stasis,and s

关 键 词：原发性肝癌 肝动脉栓塞综合征 中医药 数据挖掘 用药规律 中医传承计算平台 网络药理学 分子对接 

分 类 号：R28[医药卫生—中药学] R543[医药卫生—中医学]