盐酸胺碘酮注射液与葡萄糖注射液配伍在不同材质给药器具中的稳定性  

Stability of amiodarone hydrochloride injection and glucose injection in different drug delivery devices

作　　者：薛晓 陈辰 曾垂宇 XUE Xiao;CHEN Chen;ZENG Chuiyu(SPH No.1 Biochemical&Pharmaceutical Co.,Ltd.,Shanghai 200240,China;Shanghai SPH Innovative Pharmaceutical Technology Co.,Ltd.,Shanghai 200020,China)

机构地区：[1]上海上药第一生化药业有限公司,上海200240 [2]上海上药创新医药技术有限公司,上海200020

出　　处：《上海医药》2023年第11期75-79,共5页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:考察盐酸胺碘酮注射液在不含酞酸二乙酯(diethyl phthatate,DEP)的不同材质给药器具中和葡萄糖注射液的配伍稳定性。方法:根据盐酸胺碘酮注射液用法用量的要求,用葡萄糖注射液配制不同浓度的胺碘酮注射液,测定其在不含DEP的不同材质输液器、中心静脉导管、注射器中的稳定性。结果:盐酸胺碘酮注射液中苯甲醇在内层涂料热塑性聚氨酯材质的输液器中出现微量的吸附,其他各考察指标无明显变化。结论:盐酸胺碘酮注射液在不含DEP的不同材质给药器具中与葡萄糖注射液配伍稳定。Objective:To investigate the compatibility stability of amiodarone hydrochloride injection with glucose injection in drug delivery devices consisting of different materials without diethyl phthatate(DEP).Methods:Different concentrations of amiodarone were prepared with glucose injection according to the requirements of its usage and dosage and its stability in infusion sets,central venous catheters and syringes without DEP was determined.Results:The benzyl alcohol in the amiodarone hydrochloride injection was slightly adsorbed in the infusion set with the inner coating made of thermoplastic polyurethanes(TPU),while there was no significant change in other indicators.Conclusion:The compatibility of amiodarone hydrochloride injection in DEHP-free drug delivery devices made of different materials with glucose injection is stable.

关 键 词：盐酸胺碘酮 输液器 中心静脉导管 葡萄糖注射液 配伍 

分 类 号：R972.2[医药卫生—药品]