JAK2/STAT3通路介导原发性高血压发病机制的研究进展  

Research progress of JAK2/STAT3 pathway mediated-essential hypertension pathogenesis

作　　者：朱瑞松 石静[1] 薛红杰[1] 孔一慧[1] ZHU Rui-song;SHI Jing;XUE Hong-jie;KONG Yi-hui(Department of Cardiology,First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150001

出　　处：《心血管康复医学杂志》2023年第3期244-247,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家自然科学基金项目(81900374)。

摘　　要：JAK/STAT信号通路在生物体中广泛存在,通过介导各种细胞因子的分泌发挥相应的生物学效应,并可通过诱导白介素-6分泌增多参与高血压的形成。探究JAK/STAT通路与高血压的联系成为新的研究热点,并有助于寻找新的药物治疗靶点。The JAK/STAT signaling pathway is widely existed in organisms,and plays a corresponding biological effect by mediating secretion of various cytokines,and is involved in the formation of hypertension by inducing increased interleukin-6 secretion.Exploring the association between the JAK/STAT pathway and hypertension has become a new research hotspot and contributes to the search for new therapeutic targets for antihypertensive drugs.

关 键 词：高血压 JANUS激酶2 STAT3转录因子 血管紧张素类 

分 类 号：R544.1[医药卫生—心血管疾病]