沙门菌Ⅵ型分泌系统组装、结构特征和分泌调控网络的研究进展  

Research Process of Assembly,Structural Features,and Secretion Regulatory Networks of Type VI Secretion System in Salmonella

作　　者：陈松彪 尚珂[1,2,3] 杜付熙 余祖华[1,2,3] 李静 贾艳艳 廖成水[1,2,3] 张春杰 丁轲[1,2,3] 程相朝[1,2,3] CHEN Songbiao;SHANG Ke;DU Fuxi;YU Zuhua;LI Jing;JIA Yanyan;LIAO Chengshui;ZHANG Chunjie;DING Ke;CHENG Xiangchao(Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control,Henan University of Science and Technology,Luoyang 471023,Henan,China;Laboratory of Functional Microbiology and Animal Health,Henan University of Science and Technology,Luoyang 471003,Henan,China;College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]洛阳市活载体生物材料与动物疫病防控重点实验室,洛阳471003 [2]河南科技大学功能微生物与畜禽健康实验室,洛阳471003 [3]河南科技大学动物科技学院,洛阳471003

出　　处：《畜牧兽医学报》2023年第6期2252-2263,共12页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：河南省自然科学基金资助项目(232300421263);河南科技大学博士启动基金资助项目(13480104)

摘　　要：Ⅵ型分泌系统(type Ⅵ secretion system, T6SS)是革兰阴性菌中广泛存在的一种“分泌装置”和“杀伤机器”,其功能是将细菌毒素输送至原核或真核细胞中从而抑制/杀灭它们。T6SS在沙门菌致病过程中发挥着重要作用,能够独立编码5套T6SSs(T6SS-1~T6SS-5),分别由沙门菌毒力岛6(SPI-6)、毒力岛19(SPI-19)、毒力岛20(SPI-20)、毒力岛21(SPI-21)和毒力岛22(SPI-22)编码。T6SS参与沙门菌的种间竞争、生物被膜形成、金属离子摄取运输以及与宿主细胞相互作用,在沙门菌生活周期中发挥不可或缺的作用。本文主要综述沙门菌T6SS组装、基因组结构特征以及分泌调控网络最新研究进展,为深入研究沙门菌致病机制以及开发新的抗菌策略提供理论指导。Type VI secretion system(T6SS)is a widespread“secretion device”and“killing machine”in Gram-negative bacteria,which transmits bacterial toxins to prokaryotic or eukaryotic cells to inhibit or kill them.T6SS plays an important role in the pathogenic process of Salmonella,it can independently code five sets of T6SSs(T6SS-1-T6SS-5),which are respectively coded by Salmonella pathogenicity island 6(SPI-6),SPI-19,SPI-20,SPI-21,and SPI-22.In addition,T6SS participates in the interspecific competition of Salmonella,biofilm formation,metal ion uptake and transportation,and interaction with host cells,playing an essential role in the life cycle of Salmonella.This article mainly reviews the assembly,genomic structural characteristics,and the latest research progress of secretion regulation network of T6SS in Salmonella,providing theoretical guidance for in-depth research on the pathogenic mechanism of Salmonella and the development of new antibacterial strategies.

关 键 词：沙门菌 T6SS 组装 结构特征 分泌调控网络 

分 类 号：S852.61[农业科学—基础兽医学]