铁死亡在细菌性感染中的研究进展  

Research Progress of Ferroptosis in Bacterial Infection

作　　者：毛鹏 王志浩 李建基[1,2,3] 崔璐莹[1,2,3] 朱国强 孟霞 董俊升[1,2,3] 王亨 MAO Peng;WANG Zhihao;LI Jianji;CUI Luying;ZHU Guoqiang;MENG Xia;DONG Junsheng;WANG Heng(Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;International Research Laboratory of Prevention and Control of Important Animal Infectious Diseases and Zoonotic Diseases of Jiangsu Higher Education Institutions,Yangzhou 225009,China;Joint International Research Laboratory of Agriculture and Agri-Product Safety,the Ministry of Education,Yangzhou 225009,China)

机构地区：[1]扬州大学兽医学院江苏省动物重要疫病与人兽共患病防控协同创新中心,扬州225009 [2]江苏高校动物重要疫病和重要人兽共患病防控技术国际合作联合实验室,扬州225009 [3]农业与农产品安全教育部国际联合研究实验室,扬州225009

出　　处：《畜牧兽医学报》2023年第6期2280-2287,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(32273070);江苏省自然科学基金面上项目(BK20211324);江苏现代农业产业技术体系建设专项资金(JATS[2022]499);江苏省333高层次人才培养工程资助项目;高等学校学科创新引智计划资助(D18007);江苏高校优势学科建设工程资助项目;江苏高校动物重要疫病和重要人兽共患病防控技术国际合作联合实验室资助;江苏高校品牌专业建设工程资助项目。

摘　　要：铁死亡是一种新型程序性细胞死亡模式,其主要特点为铁依赖的脂质过氧化物蓄积。在细菌感染宿主细胞的过程中,铁代谢紊乱和氧化应激起到了重要作用,并且已经证明某些细菌可通过铁死亡的方式诱导宿主细胞死亡。本文就细菌感染对宿主铁代谢的影响以及细菌诱导铁死亡的研究现状进行阐述,以期为防控动物细菌感染提供新的思路。Ferroptosis is a newly discovered programmed cell death pattern characterized by iron-dependent accumulation of lipid peroxidation.Iron metabolism disorder and oxidative stress play an important role in bacterial infection,and it has been proved that some bacteria could induce host cell death by ferroptosis.In this paper,the effects of bacterial infection on host iron metabolism and the mechanism of bacteria-induced ferroptosis were reviewed,in order to provide new research ideas for the prevention of bacterial infection in animals.

关 键 词：铁死亡 细菌感染 铁代谢 氧化应激 

分 类 号：S855.1[农业科学—临床兽医学]