醋酸阿托西班联合盐酸屈他维林对冻融胚胎移植临床结局的影响  

Effect of Atosiban Acetate combined with Drotaverine Hydrochloride on clinical outcomes of frozen-thaw embryo transfer

作　　者：刘人杰 杜旭园 刘炜[1] 谭宗建[1] LIU Renjie;DU Xuyuan;LIU Wei;TAN Zongjian(Department of Reproductive Medicine,Guizhou Provincial People’s Hospital,Guizhou Province,Guiyang 550002,China)

机构地区：[1]贵州省人民医院生殖医学科,贵州贵阳550002

出　　处：《妇儿健康导刊》2023年第11期64-67,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨醋酸阿托西班与盐酸屈他维林联合用药在冻融胚胎移植中的临床应用价值。方法回顾性分析2020年11月至2022年1月在贵州省人民医院行冻融胚胎移植、有过一次胚胎移植失败的132例患者的临床资料,根据治疗方法将研究对象分为三组。A组67例,采用屈他维林治疗,移植日起口服盐酸屈他维林80 mg tid至移植后第10天;B组33例,采用阿托西班组治疗,移植前30 min静推醋酸阿托西班6.75 mg/0.9 ml;C组32例,采用屈他维林与阿托西班联合治疗,移植前30 min静推醋酸阿托西班6.75 mg/0.9 ml,移植日起口服盐酸屈他维林80 mg tid至移植后第10天。比较三组的人绒毛膜促性腺激素(HCG)阳性率、临床妊娠率、胚胎着床率、流产率及活产率。结果C组HCG阳性率、临床妊娠率、胚胎着床率、活产率均高于A组、B组,而流产率低于A组、B组,但差异无统计学意义(P>0.05)。结论醋酸阿托西班联合盐酸屈他维林序贯应用于一次胚胎移植失败再次冻融胚胎移植患者,对HCG阳性率、胚胎着床率、临床妊娠率及活产率有提升的趋势,对流产率有降低的趋势,但无统计学意义。Objective To discuss the application value of Atosiban Acetate combined with Drotaverine Hydrochloride in the frozen-thaw embryo transfer.Methods The clinical data of 132 patients who underwent frozen-thaw embryo transfer and had one failed embryo transfer in Guizhou Provincial People’s Hospital from November 2020 to January 2022 were retrospectively analyzed,and the study subjects were divided into three groups according to the treatment method.Group A,67 cases,was treated with Drotaverine,oral Drotaverine Hydrochloride 80 mg tid on the day of transplantation until the 10th day after transplantation.In group B,33 cases,treated with Atosiban,Atosiban Acetate 6.75 mg/0.9 ml was administered intravenously 30 min before transplantation.In group C,32 cases were treated with a combination of Drotaverine and Atosiban,Atosiban Acetate 6.75 mg/0.9 ml was administered 30 min before transplantation,and Drotaverine Hydrochloride 80 mg tid was given orally from the transplantation date until the 10th day after transplantation.The human chorionic gonadotropin(HCG)positive rate,clinical pregnancy rate,embryo implantation rate,abortion rate and live birth rate in the three groups were compared.Results The HCG positive rate,clinical pregnancy rate,embryo implantation rate,and live birth rate were higher in group C than those in group A and B,while the abortion rate was lower than that in group A and B,but the differences were not statistically significant(P>0.05).Conclusion The sequential application of Atosiban Acetate combined with Drotaverine Hydrochloride shows a tendency to enhance the HCG positive rate,embryo implantation rate,clinical pregnancy rate and live birth rate,and a tendency to reduce the abortion rate in patients who undergo frozen-thaw embryo transfer after one failed embryo transfer,but there are no statistical differ ences.

关 键 词：盐酸屈他维林 醋酸阿托西班 冻融胚胎移植 临床妊娠率 

分 类 号：R711.6[医药卫生—妇产科学]