光动力治疗子宫切除术后阴道上皮内瘤变的临床疗效及安全性观察  

Clinical efficacy and safety of photodynamic treatment of vaginal intraepithelial neoplasia after hysterectomy

作　　者：卞干霞 李洁华 周丹丹 薛金玲 Bian Ganxia;Li Jiehua;Zhou Dandan;Xue Jinling(Department of Obstetrics and Gynecology,Yancheng First People's Hospital,Yancheng,Jiangsu 224000,China)

机构地区：[1]盐城市第一人民医院妇产科,江苏盐城224000

出　　处：《实用妇科内分泌电子杂志》2023年第2期7-9,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的 探讨光动力治疗子宫切除术后阴道上皮内瘤变的临床疗效及安全性。方法 选取72例子宫切除术后阴道上皮内瘤变患者,按照随机分组对照原则将其分为对照组与试验组,每组36例。对照组采取射频消融治疗,试验组采取单纯光动力治疗。比较两组临床效果及安全性。结果 试验组总有效率88.89%高于对照组的69.44%,差异有统计学意义(P<0.05)。试验组治疗3个月后及治疗6个月后人乳头瘤病毒(HPV)转阴率均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 光动力疗法用于子宫切除术后阴道上皮内瘤变治疗的疗效显著,可促进患者HPV转阴,提高临床治愈率,且安全性较高。Objective To investigate the clinical efficacy and safety of photodynamic treatment of vaginal intraepithelial neoplasia after hysterectomy.Methods 72 cases of patients with vaginal intraepithelial neoplasia after hysterectomy were selected and divided into control group and experimental group according to the principle of randomized control,with 36 cases in each group.The control group received radiofrequency ablation and the experimental group received photodynamic therapy alone.The clinical effect and safety of the two groups were compared.Results The total effective rate of test group was 88.89%higher than that of control group(69.44%),and the difference was statistically significant(P<0.05).The negative conversion rate of human papillomavirus(HPV)in experimental group was higher than that in control group after 3 and 6 months of treatment,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Photodynamic therapy is effective in the treatment of post-hysterectomy vaginal intraepithelial neoplasia,which can promote negative HPV conversion in patients,improve the clinical cure rate,and has high safety.

关 键 词：子宫切除术 阴道上皮内瘤变 光动力治疗 射频消融治疗 临床疗效 安全性 

分 类 号：R713.4[医药卫生—妇产科学]