抗GBS类抗生素联合利托君治疗对未足月胎膜早破患者宫缩抑制的影响  

Effect of Anti-GBS Antibiotics Combined with Ritodrine on Uterine Contraction Suppression in Patients with Preterm Premature Rupture of Membranes

作　　者：刘桂英 LIU Guiying(Department of Obstetrics and Gynecology,Wuyishan Hospital of Traditional Chinese Medicine,Fujian Province,Wuyishan,Fujian Province,354300 China)

机构地区：[1]福建省武夷山市中医院妇产科,福建武夷山354300

出　　处：《中外医疗》2023年第10期111-115,共5页China & Foreign Medical Treatment

摘　　要：目的探析抗B族链球菌(group B Streptococcus,GBS)类抗生素联合利托君治疗对未足月胎膜早破患者宫缩抑制的影响。方法方便选取2016年5月—2021年5月福建省武夷山市中医院治疗的胎膜早破患者96例,采用电脑随机分组,将其分为参照组与治疗组,各48例。参照组采取抗GBS类抗生素治疗,治疗组在参照组基础上进行利托君治疗,比较两组患者临床疗效、宫缩抑制时间和孕周延长时间、炎症指标、不良反应发生情况。结果治疗组总有效率为95.83%高于参照组的77.08%,差异有统计学意义(χ^(2)=7.207,P<0.05);治疗组宫缩抑制时间、延长孕周时间及产后出血量均优于参照组,差异有统计学意义(t=11.310、31.350、10.200,P<0.05);治疗后,治疗组NF-κBP65、TREM-1指标均低于参照组,差异有统计学意义(t=7.307、10.110,P<0.05);治疗组不良反应发生率为6.25%与参照组的10.41%比较,差异无统计学意义(P>0.05)。结论针对孕周在28~34+6周胎膜早破患者,采取抗GBS类抗生素联合利托君治疗,可以提高其疗效,改善患者的宫缩抑制时间和孕周延长时间,使其炎症指标下降,且安全性较高。Objective To explore and study the effect of anti-GBS antibiotics combined with ritodrine on uterine contraction suppression in patients with preterm premature rupture of membranes.Methods 96 cases of premature rupture of membranes treated in Wuyishan Hospital of Traditional Chinese Medicine from May 2016 to May 2021 were convenient selected and randomly grouping using computers divided into a reference group and a treatment group,with 48 cases in each group.The reference group was treated with anti GBS antibiotics,while the treatment group was treated with rituximab on the basis of the reference group.The clinical treatment efficacy,uterine contraction inhibition time,gestational week extension time,inflammatory indicators,and incidence of adverse reactions were compared between the two groups of patients.Results The total effective rate of the treatment group was 95.83%,which was higher than the reference group's 77.08%,the difference was statistically significant(χ^(2)=7.207,P<0.05).The treatment group showed significantly better uterine contraction inhibition time,prolonged gestational week,and postpartum bleeding compared to the control group,the difference was statistically significant(t=11.310,31.350,10.200,P<0.05).After treatment,the treatment group NF-κBP65 and TREM-1 indicators were lower than the reference group,the difference was statistically significant(t=7.307,10.110,P<0.05).The incidence of adverse reactions in the treatment group was 6.25%,and there was no statistically significant difference compared to 10.41%in the reference group(P>0.05).Conclusion For patients with premature rupture of membranes at 28 weeks to 34+6 weeks of gestation,anti-GBS antibiotics combined with ritodrine treatment can improve the curative effect,improve the time of uterine contraction inhibition and prolongation of gestational weeks.The inflammatory index is reduced,and the safety is high.

关 键 词：抗GBS类抗生素 利托君 未足月胎膜早破 宫缩抑制 

分 类 号：R714[医药卫生—妇产科学]