51例食管小细胞癌非手术治疗患者的预后生存分析  

Prognosis and Survival Analysis of 51 Patients with Esophageal Small Cell Carcinoma Treated Without Operation

作　　者：张伟[1] 袁婕 王捷忠[1] ZHANG Wei;YUAN Jie;WANG Jiezhong(School of Clinical Oncology,Fujian Medical University,Fujian Cancer Hospital,Fuzhou,Fujian Province,350014 China;Fujian Institute of Health Professions and Technology,Fuzhou,Fujian Province,350014 China)

机构地区：[1]福建医科大学肿瘤临床医学院(福建省肿瘤医院),福建福州350014 [2]福建卫生职业技术学院,福建福州350014

出　　处：《中外医疗》2023年第11期34-38,共5页China & Foreign Medical Treatment

摘　　要：目的分析影响食管小细胞癌患者接受非手术治疗的预后因素。方法回顾性选取2012年10月—2020年12月福建省肿瘤医院51例病理确诊的食管小细胞癌患者的临床资料。统计患者的无进展生存期(PFS)、生存期(OS),并采用Kaplan-Meier法单因素分析及COX回归模型分析年龄、性别、吸烟、饮酒、病理、分段、TNM分期、化疗周期数、放疗、一线治疗后疗效评价、进展原因等因素对患者生存时间的影响。结果单因素分析中,无放疗的食管小细胞癌非手术治疗患者生存时间中位数是13个月,要显著低于放疗患者的生存时间中位数31个月,差异有统计学意义(χ^(2)=11.264,P=0.001)。COX回归分析结果:放疗是食管小细胞癌非手术治疗患者生存时间的独立影响因素(HR=0.32,95%CI:0.13~0.80,P=0.01),其他因素不是食管小细胞癌非手术治疗患者生存时间的独立影响因素。结论放疗是影响食管小细胞癌非手术治疗患者预后的独立因素。Objective To analyze the prognostic factors of patients with esophageal small cell carcinoma receiving non-surgical treatment.Methods From October 2012 to December 2020,51 patients with esophageal small cell carcinoma diagnosed by pathology in Fujian Cancer Hospital were retrospective selected of clinical data.Progression-free survival(PFS)and survival(OS)were analyzed.Kaplan-Meier univariate analysis and COX regression model were used to analyze the effects of age,gender,smoking,alcohol consumption,pathology,staging,TNM staging,number of chemotherapy cycles,radiotherapy,efficacy evaluation after first-line treatment,and cause of progression on the survival time of patients.Results In univariate analysis,the median survival time of patients treated without radiotherapy was 13 months,which was significantly lower than the median survival time of patients treated with radiotherapy(31 months),and the difference was statistically significant(χ^(2)=11.264,P=0.001).COX regression analysis showed that radiotherapy was an independent factor for survival time of patients treated with non-surgical treatment for esophageal small cell carcinoma(HR=0.32,95%CI:0.13-0.80,P=0.01),while other factors were not independent factors for survival time of patients treated with non-surgical treatment for esophageal small cell carcinoma.Conclusion Radiotherapy is an independent factor affecting the prognosis of patients with esophageal small cell carcinoma treated without surgery.

关 键 词：食管小细胞癌 非手术治疗 预后 影响因素 

分 类 号：R5[医药卫生—内科学]