安罗替尼三线治疗老年晚期结直肠癌患者的临床应用效果与安全性  

Clinical Effect and Safety of Anlotinib in Third-line Treatment of Elderly Patients with Advanced Colorectal Cancer

作　　者：林雪 郭秀梅[1] 梁蕾 LIN Xue;GUO Xiumei;LIANG Lei(Department of Oncology,Jilin People's Hospital,Jilin,Jilin Province,132000 China)

机构地区：[1]吉林市人民医院肿瘤科,吉林吉林132000

出　　处：《中外医疗》2023年第12期157-160,共4页China & Foreign Medical Treatment

基　　金：吉林省卫生健康科技能力提升项目(2022LC144)。

摘　　要：目的分析老年晚年结直肠癌患者应用安罗替尼三线治疗方式的临床效果与安全性。方法方便抽选2018年1月—2021年8月吉林市人民医院收治的56例老年晚期结直肠癌作为研究对象,以单盲分组方法划分组别,其中参照组患者28例,利用雷替曲塞联合伊立替康展开临床治疗,观察组患者28例,实施安罗替尼三线治疗,对两组患者的临床效果、应用安全性与血清癌胚抗原指标进行比较。结果观察组临床疾病缓解率(89.29%)显著高于参照组,差异有统计学意义(χ^(2)=6.095,P=0.013);观察组患者血清癌胚抗原指标为(14.56±2.82)ng/mL,明显低于参照组,差异有统计学意义(t=5.161,P<0.001)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论安替罗尼三线治疗老年晚期结直肠癌患者能够明显提升临床治疗效果,有助于改善患者预后效果,提高临床治疗安全性,值得在临床中大力推荐。Objective To analyze the clinical effect and safety of third-line treatment with anlotinib in elderly patients with colorectal cancer.Methods A total of 56 elderly patients with advanced colorectal cancer admitted to Jilin People's Hospital from January 2018 to August 2021 were conveniently selected as the research objects.The groups were divided by single-blind grouping method,and 28 patients in the reference group were treated with raltitrexed combined with irinotecan.28 patients in the observation group received third-line treatment with anlotinib.The clinical effects,application safety and serum carcinoembryonic antigen indexes of the two groups of patients were compared.Results The clinical disease remission rate(89.29%)in the observation group was significantly higher than that in the reference group,the difference was statistically significant(χ^(2)=6.095,P=0.013).The serum carcinoembryonic antigen index in the observation group was(14.56±2.82)ng/mL,which was significantly lower than that in the reference group,and the difference was statistically significant(t=5.161,P<0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The third-line treatment of antironib in elderly patients with advanced colorectal cancer can significantly improve the clinical treatment effect,help to improve the prognosis of patients,and improve the safety of clinical treatment.

关 键 词：安替罗尼 安全性 不良反应 治疗效果 预后 

分 类 号：R5[医药卫生—内科学]