复方多黏菌素B软膏联合重组人表皮生长因子治疗糖尿病皮肤难愈性溃疡的疗效分析  

Curative Effect Analysis of Compound Polymyxin B Ointment Combined with Recombinant Human Epidermal Growth Factor in the Treatment of Diabetic Skin Ulcers

作　　者：刘国兴[1] LIU Guoxing(Department of Dermatology,Nanping Center for Disease Control and Prevention,Nanping,Fujian Province,353000 China)

机构地区：[1]福建省南平市疾病预防控制中心皮肤科,福建南平353000

出　　处：《糖尿病新世界》2023年第7期72-75,共4页Diabetes New World Magazine

摘　　要：目的研究复方多黏菌素B软膏联合重组人表皮生长因子应用于糖尿病皮肤难愈性溃疡中的效果。方法纳入2021年1月—2022年3月福建省南平市疾病预防控制中心收治的70例糖尿病皮肤难愈性溃疡患者,使用随机数表法分组,对照组使用复方多黏菌素B软膏治疗(共35例),研究组使用复方多黏菌素B软膏联合重组人表皮生长因子治疗(共35例),对比两组治疗效果。结果研究组治疗后空腹血糖、餐后2 h血糖水平以及溃烂面积比对照组低;相比于对照组,研究组治疗总有效率更高,生肌时间、祛腐时间、愈合时间和换药次数更低,差异有统计学意义(P<0.05)。结论使用复方多黏菌素B软膏联合重组人表皮生长因子对糖尿病皮肤难愈性溃疡患者实施治疗,能降低患者血糖水平,促进溃疡愈合。Objective To study the effect of compound polymyxin B ointment combined with recombinant human epidermal growth factor on diabetic refractory skin ulcer.Methods A total of 70 diabetic patients with refractory skin ulcers admitted to the Nanping Center for Disease Control and Prevention of Fujian Province from January 2021 to March 2022 were included.Random number table method was used to divide the patients into groups.The control group was treated with compound polymyxin B ointment(35 cases in total),and the study group was treated with compound polymyxin B ointment combined with recombinant human epidermal growth factor(35 cases in total).The treatment effects of the two groups were compared.Results After treatment,the fasting blood glucose,two-hour postprandial blood glucose level,and ulceration area score of the study group were lower than those of the control group;compared with the control group,the total treatment effective rate of the study group was higher,and the muscle growth time,rot removal time,healing time and dressing times were lower,and the difference was statistically significant(P<0.05).Conclusion Using compound polymyxin B ointment combined with recombinant human epidermal growth factor to treat patients with diabetic refractory skin ulcers can reduce blood sugar levels and promote ulcer healing.

关 键 词：重组人表皮生长因子 复方多黏菌素B软膏 糖尿病 皮肤难愈性溃疡 

分 类 号：R587.1[医药卫生—内分泌]