血液透析滤过与低通量血液透析治疗糖尿病并重症肾衰竭患者的疗效评价  

Efficacy Evaluation of Hemodiafiltration and Low Flux Hemodialysis in the Treatment of Diabetic Patients with Severe Renal Failure

作　　者：陈国海 戴芳琳 钱文举 CHEN Guohai;DAI Fanglin;QIAN Wenju(Department of Critical Care Medicine,Anxi County Hospital,Anxi,Fujian Province,362400 China)

机构地区：[1]安溪县医院重症医学科,福建安溪362400

出　　处：《糖尿病新世界》2023年第7期180-183,共4页Diabetes New World Magazine

摘　　要：目的探讨血液透析滤过与低通量血液透析治疗糖尿病并重症肾衰竭患者的疗效。方法选取2021年1—12月安溪县医院重症医学科收治的80例糖尿病并重症肾衰竭患者,按照随机数表法分为对照组和观察组,各40例。对照组采用低通量血液透析治疗,观察组采用血液透析滤过治疗。比较两组患者治疗前后的肾功能、炎性因子指标、并发症以及治疗前后生活质量评分。结果治疗前,两组患者肾功能指标对比,差异无统计学意义(P>0.05);治疗后,观察组PTH、β2-MG、Scr指标水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者炎性因子指标对比,差异无统计学意义(P>0.05);治疗后,观察组TNF-α、IL-6指标水平低于对照组,差异有统计学意义(P<0.05)。观察组透析并发症(高血压、低血压、皮肤瘙痒、缺血性心脏病变、肌肉痉挛)发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者生活质量评分对比,差异无统计学意义(P>0.05);治疗后,观察组心理功能、社会功能、物质生活及躯体功能评分高于对照组(P<0.05)。结论血液透析滤过疗法和低通量血液透析疗法相比,患者肾功能、炎性反应改善效果更好,治疗安全性更高,治疗糖尿病并重症肾衰竭的效果更加理想,可显著提高患者的生活质量水平。Objective To investigate the efficacy of hemodialysis filtration and low-throughput hemodialysis in patients with diabetes and severe renal failure.Methods A total of 80 patients with diabetes and severe renal failure admitted to the Department of Critical Care Medicine of Anxi County Hospital from January to December 2021 were divided into control group and observation group,with 40 cases each.The control group was treated with low-throughput hemodialysis,and the observation group was treated with hemodialysis.The renal function,inflammatory factor indexes,complications,and quality of life scores before and after treatment were compared between the two groups.Results Before treatment,there was no significant difference in renal function indexes between the two groups(P>0.05);after treatment,the levels of PTH,β2-MG and SCR indexes in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,the inflammatory factor indexes of the two groups were not significantly different(P>0.05);after treatment,the levels of TNF-αand IL-6 in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The incidence of dialysis complications(hypertension,hypotension,skin itching,ischemic heart disease,muscle spasm)in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,the quality of life scores of the two groups were compared and the difference was not significant(P>0.05);after treatment,the scores of psychological function,social function,material life and physical function in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with low-throughput hemodialysis therapy,patients have better renal function and inflammatory response improvement effect,higher treatment safety,and more ideal effect in the treatment of di

关 键 词：血液透析滤过治疗 低通量血液透析治疗 糖尿病并重症肾衰竭 

分 类 号：R4[医药卫生—临床医学]