N-烷基-2,7-二硼酸频哪醇酯咔唑的合成与表征  

Synthesis and Characterization of N-alkyl-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)Carbazole

作　　者：刘畅 刘元丙 金印 李临光 杨振强[1] LIU Chang;LIU Yuan-bing;JIN Yin;LI Lin-guang;YANG Zhen-qiang(Henan Academy of Sciences Institute of Chemistry Co.Ltd.,Zhengzhou 450002,Henan,China;Qinyang Chuangan ChemicalTechnology Co.,Ltd.,Qinyang 454550,Henan,China)

机构地区：[1]河南省科学院化学研究所有限公司,河南郑州450002 [2]沁阳市创安化工科技有限公司,河南沁阳454550

出　　处：《合成材料老化与应用》2023年第3期36-38,共3页Synthetic Materials Aging and Application

基　　金：河南省科学院重大聚焦项目(210103001);河南省科学院特聘研究员项目(200503001)。

摘　　要：以2,7-二溴-9H-咔唑为初始原料,经亲电取代反应、Miyaura Borylation反应合成了一类化合物N-烷基-2,7-二硼酸频哪醇酯咔唑。利用^(1)H NMR对目标化合物的结构进行了表征;研究了反应溶剂、碱、催化剂和膦配体等因素对Miyaura Borylation反应的影响,确定了最佳反应条件:NMP为溶剂,乙酸钾为碱,Pd_(2)(dba)3为催化剂,S-PHOS为配体。A class of compounds N-alkyl-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)carbazole was synthesized by electrophonic substitution reaction and Miyaura Borylation reaction with 2,7-dibromo-9H-carbazole as the raw material.The structure of the synthesized compound was characterized by^(1)H NMR.Meanwhile,the influences of solvents,bases,catalysts and ligands on the Miyaura Borylation reaction were investigated.The optimal reaction conditions were determined:NMP was the solvent,potassium acetate was the base,Pd_(2)(dba)3 was the catalyst,S-PHOS was the ligand.

关 键 词：2 7-二溴-9H-咔唑 N-烷基-2 7-二硼酸频哪醇酯-9H-咔唑 合成与表征 

分 类 号：O62[理学—有机化学]