国家中药复方专利治疗血管性痴呆的用药规律研究  

Medication Regularity of National Patent Compound of Traditional Chinese Medicine for Vascular Dementia

作　　者：刘红喜 梁晓 申伟 魏竞竞 付国静 刘悦 迟显苏 张允岭 LIU Hongxi;LIANG Xiao;SHEN Wei;WEI Jingjing;FU Guojing;LIU Yue;CHI Xiansu;ZHANG Yunling(Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中国中医科学院西苑医院,北京100091

出　　处：《中西医结合心脑血管病杂志》2023年第10期1764-1769,共6页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家中医药管理局中医药传承与创新“百千万”人才工程项目,编号:国中医药人教发[2018]12号;国家中医药管理局中医药创新团队及人才支持计划项目(No.ZYYCXTD-C-202007);中医药防治脑病传承创新团队(No.CI2021B006);中国中医科学院科技创新工程项目(No.CI2021A01301)。

摘　　要：目的:基于数据挖掘技术研究国家专利数据库中治疗血管性痴呆(VD)的中药复方配伍规律,为VD的临床治疗及新药研发提供思路。方法:检索国家知识产权局中国专利公布公告网站建库至2022年5月1日治疗VD的中药复方专利数据,运用古今医案云平台(V2.3.5)对筛选出的中药复方进行药物频次统计、性味归经统计、功效统计、关联分析、聚类分析、复杂网络分析等数据挖掘。结果:通过检索与筛选,共纳入符合标准的中药复方67首,涉及197味中药,药物总频次548次。药物使用频次居前10位的分别是川芎、石菖蒲、丹参、黄芪、三七、人参、当归、天麻、淫羊藿、远志。药物性味归经方面,药性以温性为主,其次为平性、寒性等;药味以甘味为主,其次为苦味、辛味等;归经以肝经为主,其次为心经、脾经、肺经、肾经等。药物功效以润肠通便、滋阴养血、强筋壮骨、祛风止痛、安神益智、活血祛瘀等使用频次较高。药物关联中高频药物组合有“川芎→黄芪”“黄芪→石菖蒲”“丹参→石菖蒲”“丹参→川芎”“远志→石菖蒲”等。药物聚类可将使用频次≥8次的18味高频中药聚类成6类。复杂网络分析筛选出治疗VD的核心组方为黄芪、川芎、丹参、三七、石菖蒲、远志、熟地、当归、地龙。结论:中药复方治疗VD多以“瘀、浊、虚”病机着手,注重补虚泻实、标本兼治、疏通脑窍,常用益气活血、滋阴养血、活血化瘀、化浊开窍、通络益智、润肠通便、扶正固本之品,可为VD的临床治疗与新药开发提供一定参考。Objective:Based on the data mining technology,the compatibility rules of traditional Chinese medicine compounds in the national patent database for vascular dementia were studied.Methods:The patent data of traditional Chinese medicine compound for the treatment of vascular dementia from the establishment of the database to May 1,2022 in the China patent publication announcement website of the State Intellectual Property Office were retrieved,and the selected traditional Chinese medicine compound was mined using the ancient and modern medical record cloud platform(V2.3.5)for drug frequency statistics,nature and taste statistics,efficacy statistics,correlation analysis,cluster analysis,and complex network analysis.Results:Through retrieval and screening,67 Chinese herbal compounds were included,involving 197 kinds of traditional Chinese medicines,with a total frequency of 548 times.The top 10 drugs were Rhizoma Chuanxiong,Rhizoma Acori Tatarinowii,Radix Salviae Miltiorrhizae,Radix Astragali,Radix Notoginseng,Radix Ginseng,Radix Angelicae Sinensis,Rhizoma Gastrodiae,Herba Epimedii,and Radix Polygalae.They were warm in nature,followed by mild and cold in nature,sweet in taste,followed by bitter and pungent in taste,and liver meridian in meridian tropism,followed by heart,spleen,lung,and kidney meridians.The popular drugs were used for relaxing the bowels,nourishing Yin and blood,strengthening tendons and bones,expelling wind and relieving pain,calming the nerves and improving intelligence,promoting blood circulation and removing blood stasis,etc.The high frequency drug in drug association included"Ligusticum Chuanxiong→Astragalus membranaceus""Astragalus membranaceus→Acorus tatarinowii""Salvia miltiorrhiza→Acorus tatarinowii""Salvia miltiorrhiza→Ligusticum Chuanxiong"and"Polygala tenuifolia→Acoru tatarinowii".Drug clustering showed 18 kinds of high-frequency traditional Chinese medicines which were used more than 8 times in 6 categories.Complex network analysis showed the core formula for the treatment of v

关 键 词：血管性痴呆 数据挖掘 用药规律 中药复方专利 

分 类 号：R277.7[医药卫生—中医学]