基于“心房肌内环境多稳态失衡—心房纤维化”论房颤心房重构“气阴两虚、风动扰心”病机的生物学内涵  

Biological Connotation of Qi and Yin Deficiency and Wind Harassing Heart in Atrial Remodeling in Atrial Fibrillation Based on the Theory of Multi-homeostasis Imbalance in Atrial Muscle-Atrial Fibrosis

作　　者：杜柏[1] 吴华芹[1] 褚瑜光[1] 魏艺[1] 蒋雨辰 王欢[1] 胡元会[1] DU Bai;WU Hua-qin;CHU Yu-guang;WEI Yi;JIANG Yu-chen;WANG Huan;HU Yuan-hui(Department of Cardiovascular Medicine,Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053)

机构地区：[1]中国中医科学院广安门院心血管科,北京100053

出　　处：《世界中西医结合杂志》2023年第4期637-641,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：中国中医科学院科技创新工程重大公关“中西医结合心血管病学”学科(CI2021A00918)。

摘　　要：心房心肌内环境多稳态(结构、功能、电生理、血流动力学、神经内分泌)失衡,与房颤发病最终导致心房纤维化、心房重构密切相关。研究团队基于中医经典理论和既往研究,发现“气阴两虚、风动扰心”是房颤发病过程中的关键病机。结合现代医学研究及分子生物学文献,认为心房心肌内环境多稳态失衡与中医“气阴两虚”密切相关,心房纤维化异常为“风邪损伤心脉”的微观体现,且在房颤心房重构病变进程中,“心房心肌内环境多稳态失衡—心房纤维化”与中医“气阴两虚、风动扰心”相契合。从“心房心肌内环境多稳态失衡—心房纤维化”角度探讨房颤心房重构“气阴两虚、风动扰心”的生物学内涵,对于研究“气阴两虚、风动扰心”的病机实质及其中医方药防治房颤心房重构的作用具有重要意义。The imbalance of multi-homeostasis(structure,function,electrophysiology,hemodynamics,and neuro-endocrine)in atrial muscle is closely associated with atrial fibrosis and atrial remodeling in atrial fibrillation.According to the theory of traditional Chinese medicine(TCM)and available studies,we proposed that qi and yin deficiency and wind harassing heart were the key pathogeneses of atrial fibrillation.The multi-homeostasis imbalance in atrial muscle in mod-ern medicine corresponds to the TCM syndrome of qi and yin deficiency.The abnormal atrial fibrosis is the microscopic manifestation of wind damaging heart vessels.In the atrial remodeling in atrial fibrillation,multi-homeostasis imbalance in atrial muscle-atrial fibrosis is consistent with the TCM syndromes of qi and yin deficiency and wind harassing heart.Ex-ploring the biological connotation of qi and yin deficiency and wind harassing heart from multi-homeostasis imbalance in atrial muscle-atrial fibrosis is of great significance to the research on the pathogenesis of qi and yin deficiency and wind harassing heart and the role of TCM prescriptions in preventing and treating atrial remodeling in atrial fibrillation.

关 键 词：房颤 心房重构 心房纤维化 中医证型 

分 类 号：R541.7[医药卫生—心血管疾病]