消瘿散结方穴位贴敷治疗气郁痰阻证甲状腺良性结节的疗效观察  

Clinical Observation on Treating Benign Thyroid Nodules(Syndrome of Qi Stagnation and Phlegm Obstruction)with Acupoint Application of Xiaoying Sanjie Prescription

作　　者：胡燕[1] 谢培凤[1] 易文明[1] 郭翔宇[1] 王宝君[1] 胡浩 王颖[1] 薛晓轩[1] 王春红[1] 刘欢 HU Yan;XIE Pei-feng;YI Wen-ming;GUO Xiang-yu;WANG Bao-jun;HU Hao;WANG Ying;XUE Xiao-xuan;WANG Chun-hong;LIU Huan(Dongfang Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100078)

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《世界中西医结合杂志》2023年第4期783-786,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：中央高校基本科研业务专项资金-北京中医药大学青年教师项目(2017-JYB-JS-095)。

摘　　要：目的 探讨消瘿散结方外敷治疗气郁痰阻型甲状腺良性结节的临床疗效及安全性。方法 选取2019年5月—2021年4月期间北京中医药大学东方医院内分泌科就诊的80例甲状腺良性结节患者,采用随机数字表法将患者分为治疗组和对照组,每组各40例。对照组给予基础药物(小金片)治疗,治疗组在对照组基础上给予消瘿散结方穴位贴敷,4次/周,4 h/次。治疗3个月后,观察比较两组患者临床疗效,治疗前后中医证候积分、甲状腺最大结节直径大小、甲状腺功能[血清中游离三碘甲状腺原氨酸(Free triiodothyronine, FT3)、游离甲状腺素(Free Thyroxine, FT4)、血清促甲状腺素(Thyroid-stimulatinghormone, TSH)水平]变化及血常规、肝功能、肾功能、尿常规、心电图等安全性指标。结果 治疗后治疗组临床疗效73.5%(25/34)明显高于对照组57.8%(22/38),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组中医证候积分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者甲状腺结节最大直径均较治疗前明显缩小,差异有统计学意义(P<0.05);且治疗组结节大小明显小于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后甲状腺功能比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 消瘿散结方外敷可改善气郁痰阻型结节型甲状腺良性结节患者临床症状,缩小结节最大直径,对甲状腺功能无明显影响,具有较高的安全性,值得临床推广应用。Objective To observe the clinical effect of acupoint application of Xiaoying Sanjie Prescription on be-nign thyroid nodules with the syndrome of qi stagnation and phlegm obstruction.Methods Eighty patients with benign thyroid nodules(syndrome of qi stagnation and phlegm obstruction)treated in the Department of Endocrinology of Dongfang Hospital Affiliated to Beijing University of Chinese Medicine from May 2019 to April 2021 were randomly assigned into a control group(n=40)and an observation group(n=40)according to the random number table method.The control group was treated with Xiaojin Tablets,and the observation group with Xiaojin Tablets combined with acupoint application of Xi-aoying Sanjie Prescription(4 times a week,4 h each time).After 3 months of treatment,the clinical efficacy was compared between the two groups.The TCM syndrome score,thyroid maximum nodule diameter,thyroid function indicators[free triio-dothyronine(FT3),free thyroxine(FT4),and thyroid-stimulating hormone(TSH)],and safety indicators such as blood routine,liver function,renal function,urine routine,and electrocardiogram were compared between before and after treat-ment as well as between the two groups.Results The total effective rate in the observation group was 73.5%(25/34),which was higher than that(57.8%,22/38)of the control group(P<0.05).The treatment in both groups decreased the TCM syndrome score and thyroid maximum nodule diameter(P<0.05),and the observation group had lower TCM syn-drome score and thyroid maximum nodule diameter than the control group(P<0.05).The FT3,FT4,and TSH levels showed no significant differences between the two groups as well as between before and after treatment(P>0.05).The in-cidence of adverse reactions had no significant difference between the two groups(P>0.05).Conclusion The acupoint application of Xiaoying Sanjie Prescription can significantly alleviate the clinical symptoms of patients with benign thyroid nodules(syndrome of qi stagnation and phlegm obstruction)and reduce the maximum diameter of nod

关 键 词：气郁痰阻型甲状腺良性结节 消瘿散结方 外敷 

分 类 号：R581[医药卫生—内分泌]