银翘散合五味消毒饮加减对小儿急性化脓性扁桃体炎症状改善及血WBC、PCT、CRP水平的影响  

Effect of Modified Y inqiao Powder and Wuwei Xiaodu Decoction on the Improvement of Symptoms and WBC,PCT,and CRP Levels in Children with Acute Suppurative Tonsillitis

作　　者：冯海荣 王亚君 杨亚莉 李媛媛 FENG Hai-rong;WANG Ya-jun;YANG Ya-li;LI Yuan-yuan(Department of General Pediatrics,Tongzhou District Maternal and Child Health Hospital,Beijing 101110;Department of Pediatrics,Eighth Medical Center,General Hospital of the People′s Liberation Army,Beijing 100091)

机构地区：[1]北京市通州区妇幼保健院普儿科,北京101110 [2]解放军总医院第八医学中心儿科,北京100091

出　　处：《世界中西医结合杂志》2023年第5期1018-1022,1040,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：北京市通州区科技计划项目(KJ2020CX015)。

摘　　要：目的 探讨银翘散合五味消毒饮加减对小儿急性化脓性扁桃体炎症状改善及血白细胞计数(White blood cell count, WBC)、降钙素原(Procalcitonin, PCT)、C反应蛋白(C-reactive protein, CRP)水平的影响。方法 选取2020年2月—2021年2月期间北京市通州区妇幼保健院普儿科收治的86例急性化脓性扁桃体炎患儿作为研究对象,按照随机数字表法分为对照组和观察组,每组各43例。对照组患儿均采用常规西医治疗方法,观察组在对照组基础上联合银翘散合五味消毒饮加减治疗。治疗5 d后,观察比较两组患儿治疗后临床症状消失时间、临床总有效率及安全性,观察比较两组患儿治疗前后中医证候积分(扁桃体充血、扁桃体肿大、扁桃体化脓、咽痛、发热、便干)、WBC、PCT、CRP水平。结果 治疗后两组患儿扁桃体充血、扁桃体肿大、扁桃体化脓、咽痛、发热、便干中医证候积分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组中医证候积分均低于对照组,差异有统计学意义(P<0.05)。治疗后观察组扁桃体消肿时间、扁桃体脓性分泌物消失时间、退热时间及咽痛消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿血WBC、PCT、CRP水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组总有效率95.3%(41/43)明显高于对照组76.7%(33/43)(P<0.05)。两组患儿治疗前后及治疗期间血常规、尿常规、肾功能、肝功能及一般体格指标均无异常变化,治疗期间均未发生与治疗药物相关的不良反应。结论 银翘散合五味消毒饮加减联合西药能够显著改善急性化脓性扁桃体炎患儿临床症状,降低WBC、PCT、CRP水平,促进炎症吸收,缩短病程,且不良反应少,疗效十分显著。Objective To explore the effect of Yinqiao Powder and Wuwei Xiaodu Decoction on the improvement of acute suppurative tonsillitis symptoms in children and the levels of white blood cell count(WBC),procalcitonin(PCT),and C-reactive protein(CRP).Methods A total of 86 children with acute suppurative tonsillitis admitted to the Depart-ment of General Pediatrics of Tongzhou District Maternal and Child Health Hospital in Beijing from February 2020 to Feb-ruary 2021 were selected as the study subjects.They were divided into a control group and an observation group by using a random number table method,with 43 cases in each group.The children in the control group were treated with conventional Western medicine,while those in the he observation group were treated with modified Yinqiao Powder and Wuwei Xiaodu Decoction on the basis of the control group.After five days of treatment,the disappearance time of clinical symptoms,total clinical effective rate,and safety were compared between the two groups.This article also observed and compared the TCM syndrome scores(tonsillar congestion,tonsillar enlargement,tonsillar suppuration,pharyngodynia,fever,and dry stool)before and after treatment,as well as the WBC,PCT,and CRP levels.Results After treatment,the TCM syndrome scores of ton-sillar congestion,tonsillar enlargement,tonsillar suppuration,pharyngodynia,fever,and dry stool in the two groups of chil-dren were significantly reduced(P<0.05);moreover,the TCM syndrome scores of the observation group were lower than those of the control group(P<0.05).After treatment,the observation group had shorter tonsil swelling reduction time,dis-appearance time of tonsil purulent secretions,fever reduction time,and pharyngeal pain disappearance time than the control group(P<0.05);the levels of WBC,PCT,and CRP in the blood of the two groups of children were significantly reduced(P<0.05).In addition,the observation group was significantly lower than the control group(P<0.05).After treatment,the total effective rate of 95.3%(41/43)in the observa

关 键 词：小儿急性化脓性扁桃体炎 银翘散合五味消毒饮加减 白细胞计数 降钙素原 C反应蛋白 

分 类 号：R766.18[医药卫生—耳鼻咽喉科]