盐酸氨溴索联合常规规范化治疗对小儿哮喘急性发作临床效果  

Clinical Effect of Ambroxol Hydrochloride Combined with Routine and Standardized Treatment on Acute Asthma Attack in Children

作　　者：高琳 GAO Lin(Pediatric Department,Yongdeng County People's Hospital)

机构地区：[1]永登县人民医院儿科

出　　处：《中国标准化》2023年第10期228-231,共4页China Standardization

摘　　要：目的:探究盐酸氨溴索联合常规规范化治疗对小儿哮喘急性发作临床效果。方法:选择2021年1月至2022年1月我院收治82例小儿哮喘急性发作患儿,以随机数字表法分成两组。对照组给予常规规范化治疗病例数41例,试验组在对照组基础上加用盐酸氨溴索治疗病例数41例,比较临床治疗效果、疾病症状消失时间、肺功能、炎症因子。结果:临床治疗总有效率组间对比更高的一组为试验组,组间差异显著(P<0.05)。试验组咳嗽消失时间、气促消失时间、喘息消失时间、肺部啰音消失时间均明显短于对照组,差异有统计学意义(P<0.05)。两组治疗前第1秒用力呼气容积、用力肺活量、最大呼气峰流速无显著差异。治疗后,两组FEV1、FVC、PEF水平均显著提升,试验组高于对照组(P<0.05)。治疗前,两组炎症因子白介素4、白介素13、干扰素γ比较,差异无统计学意义;治疗后,两组炎症因子均下降,与治疗前比较差异显著;试验组治疗后均低于对照组,差异有统计学意义(P<0.05)。结论:盐酸氨溴索联合常规规范化治疗对小儿哮喘急性发作临床效果显著,可促进疾病症状消失,能够改善肺功能、减轻炎症反应,治疗价值高。Objective:To explore the clinical effect of ambroxol hydrochloride combined with routine and standardized treatment on children with acute asthma attack.Methods:A total of 82 children with acute asthma attack in the hospital from January 2021 to January 2022 were divided into two groups by random number table method.The control group of 41 cases received routine and standardized treatment,and the experimental group of 41 cases received ambroxol hydrochloride on the basis of the control group.The clinical therapeutic effect,time of symptom disappearance,lung function and inflammatory factors were compared.Results:The group with higher total effective rate was the experimental group,and the difference between the groups was significant(P<0.05).The disappearance time of cough,shortness of breath,wheezing and pulmonary rales in the experimental group were significantly shorter than those in the control group,and the difference was statistically significant(P<0.05).Forced expiratory volume,forced vital capacity and maximum peak expiratory flow rate in the first second before treatment were not significantly different between the two groups.After treatment,the levels of FEV1,FVC and PEF in the two groups were significantly increased,and the experimental group was higher than the control group(P<0.05).Before treatment,there was no significant difference in the inflammatory factors of interleukin4,interleukinl3 and interferon between the two groups.After treatment,

关 键 词：小儿哮喘 盐酸氨溴索 常规规范化治疗 肺功能 炎症反应 

分 类 号：R725.6[医药卫生—儿科]