NB-UVB与白芍总苷胶囊联合用于银屑病患者治疗对免疫功能及皮损PASI评分的影响  

Effect of NB-UVB Combined with Total Glucosides of Paeony Capsule on Immune Function and PASI Score of Psoriasis Patients

作　　者：黄永[1] 顾礼忠[1] HUANG Yong;GU Li-zhong(Dermatological Department of Tianjin Public Security Hospital,Tianjin 300070,China)

机构地区：[1]天津市公安医院皮肤科,天津300070

出　　处：《医学信息》2023年第12期148-151,共4页Journal of Medical Information

摘　　要：目的探讨银屑病患者行窄谱中波紫外线(NB-UVB)照射治疗,并服用白芍总苷胶囊的临床效果及免疫功能改善价值。方法选取2019年2月-2021年2月在本院诊治的200例银屑病患者,经随机数字表法分为两组。对照组(100例)患者给予NB-UVB照射治疗,观察组(100例)患者给予NB-UVB照射+口服白芍总苷胶囊治疗。两组治疗时间均为8周。观察患者血清炎性因子、免疫功能指标及皮损严重程度变化情况。结果两组治疗后IL-6、IL-8及TNF-α水平均低于治疗前,且观察组低于对照组(P<0.05);两组治疗后患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于治疗前,CD8^(+)低于治疗前,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05);两组治疗后患者PASI评分低于治疗前,观察组PASI评分低于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论银屑病患者行NB-UVB照射基础上再服用白芍总苷胶囊治疗,能够有效提高抗炎及机体免疫功能改善效果,促进患者皮损程度有效减轻。Objective To investigate the clinical effect and immune function improvement value of patients with psoriasis treated with narrow-band ultraviolet B(NB-UVB)irradiation and total glucosides of paeony capsules.Methods A total of 200 patients with psoriasis diagnosed and treated in our hospital from February 2019 to February 2021 were selected.A Random number table method was used to divided the patients into two groups.The control group(100 patients)was treated with NB-UVB irradiation,and the observation group(100 patients)was treated with NB-UVB irradiation plus oral total glucosides of paeony capsule.Both groups were treated for 8 weeks.The changes of serum inflammatory factors,immune function indexes and skin lesion severity were observed.Results After treatment,the levels of IL-6,IL-8 and TNF-αin the two groups were lower than those before treatment,and the observation group showed a significant lower level of those index than the control group(P<0.05).And also had significant higher CD3^(+),CD4^(+),CD4^(+)/CD8^(+)level and lower CD8^(+)level than those before treatment,while CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,CD8^(+)was lower than that in the control group(P<0.05).The PASI score of the two groups after treatment was lower than that before treatment,and the PASI score of the observation group was lower than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of psoriasis patients with NB-UVB irradiation combined with total glucosides of paeony capsules can effectively improve the anti-inflammatory and immune function,and promote the effective reduction of skin lesions.

关 键 词：银屑病 窄谱中波紫外线 白芍总苷胶囊 炎症反应 免疫功能 皮损 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]