血清甲胎蛋白联合γ-谷氨酰转移酶检测对肝脏肿瘤良恶性的鉴别诊断价值  

Value of serum alpha-fetoprotein combined withγ-glutamyltransferase in differential diagnosis of benign and malignant liver tumors

作　　者：汪蕾 华喜梅 胡丰芬 陈晨 Wang Lei;Hua Ximei;Hu Fengfen;Chen Chen(Department of Laboratory Medicine,Department of General Surgery,Suqian First Hospital,Suqian Jiangsu 223800,China)

机构地区：[1]宿迁市第一人民医院医学检验科,江苏宿迁223800 [2]宿迁市第一人民医院普外肝胆科,江苏宿迁223800

出　　处：《青岛医药卫生》2023年第3期166-169,共4页Qingdao Medical Journal

摘　　要：目的分析血清甲胎蛋白(AFP)联合γ-谷氨酰转移酶(γ-GGT)检测对肝脏肿瘤良恶性的鉴别诊断价值。方法选取本院2018年5月~2021年5月92例肝脏恶性肿瘤患者,设为观察组,另随机选取同期86例肝脏良性肿瘤,设为常规组。观察组,其中男50例,女42例,年龄30~66岁,平均(48.24±5.31)岁,另选取同期的肝脏良性肿瘤患者86例,设为常规组,其中男46例,女40例,年龄30~66岁,平均(49.28±6.12)岁。计量资料以均数±标准差(±s)表示,比较采用t检验;计数资料以构成比或率(%)表示,比较做χ2检验;2组检测AFP、γ-GGT水平并对比。并采用受试者工作特征曲线(ROC)分析联合AFP、γ-GGT水平对肝脏良恶性肿瘤患者的鉴别价值。结果观察组血清AFP、γ-GGT水平均高于常规组(P<0.05),ROC曲线分析结果显示,AFP与γ-GGT鉴别肝脏良恶性肿瘤患者的灵敏度分别为77.52%(95%CI:58.74~90.62)、75.01%(95%CI:53.41~88.13)、75.01%(95%CI:53.41~88.13),特异度分别为78.96%(95%CI:71.45~85.67)、76.98%(95%CI:69.07~83.77)、91.01%(95%CI:83.90~94.61),AUC分别为0.785(95%CI:0.671~0.862)、0.761(95%CI:0.656~0.861)、0.902(95%CI:0.835~0.962)。结论肝脏恶性肿瘤患者血清AFP、γ-GGT水平均升高,且AFP、γ-GGT水平均高于肝脏良性肿瘤患者,以上指标均具有一定的鉴别价值,但联合鉴别时的鉴别价值更高,临床中应加强对于该肝脏恶性肿瘤患者血清AFP、γ-GGT水平的检测。Objective To analyze the value of serum alpha-fetoprotein(AFP)combined withγ-glutamyltransferase(γ-GGT)detection in the differential diagnosis of benign and malignant liver tumors.Methods 92 patients with liver malignant tumor in our hospital from May 2018 to May 2021 were selected as the observation group,and 86 patients with liver benign tumor in the same period were randomly selected as the routine group.The observation group included 50 males and 42 females,aged 30-66 years,with an average age of(48.24±5.31)years.In addition,86 patients with benign liver tumors in the same period were selected as the routine group,including 46 males and 40 females,aged 30-66 years,with an average age of(49.28±6.12)years.The measurement data are expressed as mean±standard deviation,and the comparison is performed by t test;The counting data were expressed in constituent ratio or rate(%)and compared for test;Two groups tested AFPγ-GGT level and comparison.The combined AFPγ-The differential value of GGT level in patients with benign and malignant liver tumors.Results The levels of serum AFP andγ-GGT in the observation group were higher than those in the conventional group(P<0.05).ROC curve analysis showed that the sensitivity of AFP andγ-GGT in differentiating liver malignant tumor patients were 77.52%(95%CI:58.74~90.62)and 75.01%(95%CI:53.41~88.13),75.01%(95%CI:53.41~88.13),and their specificities were 78.96%(95%CI:71.45~85.67),76.98%(95%CI:69.07~83.77),91.01%(95%CI:83.90~94.61),and the AUC were 0.785(95%CI:0.671~0.862),0.761(95%CI:0.656~0.861)and 0.902(95%CI:0.835~0.962),respectively.Conclusion Serum AFPγ-GGT levels were elevated,and AFPγ-The GGT level is higher than that of patients with benign liver tumor,and the above indicators have certain differential value,but the combined differential value is higher.In clinical practice,we should strengthen the serum AFPγ-Detection of GGT level.

关 键 词：肝脏恶性肿瘤 甲胎蛋白 Γ-谷氨酰转移酶 肝脏良性肿瘤 

分 类 号：R446.1[医药卫生—诊断学] R735.7[医药卫生—临床医学]