5″-羟基大麻二酚的合成  

Synthesis of 5″-Hydroxycannabidiol

作　　者：刘忠旭 江凡 王兆麟 李航 胡春[1] 张伟[2] LIU Zhongxu;JIANG Fan;WANG Zhaolin;LI Hang;HU Chun;ZHANG Wei(School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China;School of Pharmacy,Fudan University,Shanghai 201203,China)

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016 [2]复旦大学药学院,上海201203

出　　处：《合成化学》2023年第6期445-452,共8页Chinese Journal of Synthetic Chemistry

基　　金：国家“重大新药创制”科技重大专项项目(2009ZX09301-012)。

摘　　要：大麻二酚具有多种药理活性,但因其代谢会产生一系列不良反应。为了探究大麻二酚的代谢问题和毒副作用,有必要对大麻二酚代谢产物5″-羟基大麻二酚的合成方法进行研究。以3,5-二甲氧基苯甲醛为起始原料,经过9步反应以15.2%的总收率完成了5″-羟基大麻二酚(8)的合成。此路线不仅提供了一种高效的合成5″-羟基大麻二酚的方法,也为大麻二酚衍生物的制备及代谢产物研究奠定了基础。Cannabidiol has various pharmacological activities,but it has shown a series of adverse reactions due to its metabolites.In order to explore the metabolic issues and toxic side effects of cannabidiol,It is necessary to study the synthesis method of 5″-hydroxycannabidiol,a metabolite of cannabidiol.5″-Hydroxycannabidiol was prepared in total 15.2%yield by using 3,5-dimethoxybenzaldehyde as starting material via nine steps.This strategy provides an efficient route to 5″-hydroxycannabidiol synthesis and offers a tool to cannabidiol derivatives preparation and their metabolites research.

关 键 词：大麻二酚 代谢产物 5″-羟基大麻二酚 合成 傅克烷基化 

分 类 号：O626[理学—有机化学]