生物催化技术制备手性酸医药化学品的研究进展  

Research Progress on The Biocatalytic Synthesis of Chiral Pharmaceutical Acids

作　　者：江千姿 王博[2] 姜灵 于洪巍[1] 叶丽丹 JIANG Qianzi;WANG Bo;JIANG Ling;YU Hongwei;YE Lidan(College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China;College of Chemical and Biological Engineering,Shandong University of Science and Technology,Qingdao 266590,China;Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Huzhou 313200,China)

机构地区：[1]浙江大学化学工程与生物工程学院,浙江杭州310027 [2]山东科技大学化学与生物工程学院,山东青岛266590 [3]浙江工业大学绿色制药协同创新中心,浙江湖州313200

出　　处：《合成化学》2023年第6期476-496,共21页Chinese Journal of Synthetic Chemistry

基　　金：国家重点研发计划项目(2020YFA0908400)。

摘　　要：手性酸是一类重要的有机化合物,在医药工业、农药工业等领域有着广泛的应用。生物催化法制备手性酸因其具有立体选择性高、反应条件温和和环境友好等优点而受到科研工作者的高度重视。本文综述了近年来利用生物催化技术制备手性酸医药化学品的研究进展,重点研究了生物催化技术制备非甾体抗炎药、非天然氨基酸以及其他手性酸的方法,并对该领域的研究情况进行了总结与展望。Chiral acids are an important class of organic compounds,which have found wide applications in pharmaceutical and agrochemical industries.Biocatalytic synthesis of chiral acids has attracted considerable attention due to its high stereoselectivity,mild reaction conditions and environmental friendliness.In this paper,recent advances in biocatalytic synthesis of chiral pharmaceutical acids are reviewed with emphasis on biocatalytic synthesis of non-steroidal anti-inflammatory drugs(NSAIDs),non-natural amino acids and others.Finally,the future trends are discussed.

关 键 词：生物催化 手性酸 医药化学品 非甾体抗炎药 固定化酶 3-环己烯-1-甲酸 普瑞巴林 

分 类 号：O621.3[理学—有机化学]