帕瑞昔布钠联合球后神经阻滞在眼球摘除术患者中的应用效果  

Application Effect of Parecoxib Sodium Combined with Retrobulbar Nerve Block in Patients with Enucleation Surgery

作　　者：王宇博 尚游 Wang Yubo;Shangyou(Graduate Training Base of Jinzhou Medical University in Shenyang Fourth People's Hospital,Shenyang 110000,Liaoning Province,China;The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,Liaoning Province,China)

机构地区：[1]锦州医科大学沈阳市第四人民医院研究生培养基地,辽宁沈阳121000 [2]锦州医科大学附属第一医院,辽宁沈阳121000

出　　处：《中国社区医师》2023年第15期39-41,共3页Chinese Community Doctors

摘　　要：目的:探讨帕瑞昔布钠联合球后神经阻滞对眼球摘除术患者的应用效果。方法:选取2020年1—12月于沈阳市第四人民医院行全麻下单侧眼球摘除术的40例患者作为研究对象,随机为帕瑞昔布钠联合球后神经阻滞组(P组)及对照组(S组),各20例。麻醉诱导前30 min,P组静脉滴注帕瑞昔布钠,S组静脉滴注生理盐水。两组术前均给予球后神经阻滞。比较两组平均动脉压(MAP)及心率(HR)、术中麻醉镇痛药物使用剂量、静息及咳嗽时疼痛程度、不良反应发生情况。结果:进入手术室平静时,两组MAP比较,差异无统计学意义(P>0.05);插管时、摘眼球时、拔管时、拔管后5 min,P组MAP低于S组,差异有统计学意义(P<0.05)。两组各时间点HR比较,差异无统计学意义(P>0.05)。P组丙泊酚、瑞芬太尼使用剂量均低于S组,差异有统计学意义(P<0.001)。术后2 h,两组静息时VAS评分比较,差异无统计学意义(P>0.05);咳嗽时P组疼痛评分低于S组,差异有统计学意义(P<0.001)。各时间点,P组静息及咳嗽时疼痛评分均低于S组,差异有统计学意义(P<0.05)。两组术后不良反应发生率比较,差异无统计学意义(P>0.05)。结论:帕瑞昔布钠联合球后神经阻滞能使眼球摘除术患者术中生命体征更平稳,减少术中麻醉镇痛药使用剂量,减轻术后疼痛,且安全性较高。Objective:To investigate the application effect of parecoxib sodium combined with retrobulbar nerve block in patients with enucleation surgery.Methods:A total of 40 patients with unilateral enucleation under general anesthesia in Shenyang Fourth People's Hospital from January 2020 to December 2020 were selected as the study subjects.The patients were randomly divided into parecoxib sodium combined with retrobulbar nerve block group(P group)and control group(S group),with 20 cases in each group.At 30 min before induced anesthesia,P group received intravenous injection of parecoxib sodium,and S group received intravenous injection of normal saline.Both groups were given retrobulbar nerve block before surgery.The mean arterial pressure(MAP)and heart rate(HR),intraoperative anesthetic and analgesic drug dose,pain degree at rest and coughing,and occurrence of adverse reactions were compared between the two groups.Results:When entering the operating room in calm state,there was no significant difference in MAP level between the two groups(P>0.05).At the time of intubation,eyeball extraction,extubation,and at 5 min after extubation,the MAP in P group was lower than that in S group and the difference was statistically significant(P<0.05).There was no significant difference in HR at each time point between the two groups(P>0.05).The doses of propofol and refentanil in P group were lower than those in S group,and the difference was statistically significant(P<0.001).At 2 h after surgery,there was no significant difference in the VAS scores at rest between the two groups(P>0.05).The pain score at coughing in P group was lower than that in S group,and the difference was statistically significant(P<0.001).At all time points,the pain scores at rest and coughing in P group were lower than those in S group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclusion:Parecoxib sodium combined with retrobul

关 键 词：眼球摘除术 帕瑞昔布钠 球后神经阻滞 

分 类 号：R614[医药卫生—麻醉学]