结核分枝杆菌耐药状况的Meta分析  

Meta analysis of drug resistance of Mycobacterium tuberculosis

作　　者：吴雅琼 张茜 夏礼栋 WU Yaqiong;ZHANG Qian;XIA Lidong(Laboratory Department of China Resources WISCO General Hospital,Wuhan,Hubei 430080,China)

机构地区：[1]华润武钢总医院检验科,湖北武汉430080

出　　处：《国际检验医学杂志》2023年第S01期82-85,共4页International Journal of Laboratory Medicine

摘　　要：目的分析近年来不同地区结核分枝杆菌耐药情况及其变化趋势,为改进结核病防治措施提供科学依据。方法通过电子检索收集我国2010-2021年不同地区有关结核分枝杆菌耐药性分析的文献,根据循证医学方法建立纳入和排除标准,采用Revman4.2软件对符合条件的所有研究结果进行Meta分析。结果77篇结核分枝杆菌耐药监测的文献中,12篇文献符合纳入标准,文献中包括了12167例实验对象。对初治患者结核分枝杆菌耐药情况的Meta分析表明,RR为1.40,95%可信区间为1.01~1.94。复治患者结核分枝杆菌耐药分布的Meta分析表明,RR为0.28,95%可信区间为0.16~0.48。结论初治患者单耐药的发生率较多耐药高,而复治患者中患多耐药结核病的概率较单耐药高。Objective To analyze the drug resistance and the changing trend of Mycobacterium tuberculosis in different areas in recent years,so as to provide scientific basis for improving TB control measures.Methods The literatures on the analysis of drug resistance of Mycobacterium tuberculosis in different regions of China from 2010 to 2021 were collected by electronic retrieval.The inclusion and exclusion criteria were established according to the evidence-based medicine method.All the eligible research results were Meta analyzed by revman4.2 software.Results Among the 77 literatures on drug resistance monitoring of Mycobacterium tuberculosis,12 met the inclusion criteria,including 12,167 subjects.The Meta-analysis of drug resistance of Mycobacterium tuberculosis in newly treated patients showed that the RR was 1.40 and the 95%confidence interval was 1.01-1.94.Meta analysis of drug resistance distribution of Mycobacterium tuberculosis in retreated patients showed that RR was 0.28 and 95%confidence interval was 0.16-0.48.Conclusion The incidence of single drug resistance in primary patients is higher than that of multi drug resistance,while the incidence of multi drug resistance tuberculosis in retreated patients is higher than that of single drug resistance.

关 键 词：结核分枝杆菌 耐药 META分析 

分 类 号：R446.5[医药卫生—诊断学]