血浆降钙素原、肝素结合蛋白和白细胞介素-6对重症肺炎进展早期预判的临床意义  

Plasma procalcitonin,heparin binding protein and interleukin-6 in early prediction of severe pneumonia progression

作　　者：马郡 杨旭峰[1] MA Jun;Yang Xufeng(Department of Laboratory Medicine,Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang 310009,China)

机构地区：[1]浙江大学医学院附属第二医院检验科,浙江杭州310009

出　　处：《国际检验医学杂志》2023年第S01期85-88,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨血浆降钙素原(PCT)、肝素结合蛋白(HBP)和白细胞介素-6(IL-6)对早期预判肺炎进展为重症有临床意义。方法选取2019年6月1日至2022年2月23日在该院治疗的86例肺炎患者为研究对象,将患者分为普通肺炎组42例和重症肺炎组44例,同期选取该院体检健康者50例为对照组。化学发光法检测所有受试对象血浆PCT和IL-6,免疫荧光法检测血浆HBP水平;比较对照组、肺炎组PCT、HBP和IL-6;比较对照组、重症肺炎组PCT、HBP和IL-6;比较普通肺炎组和重症肺炎组PCT、HBP和IL-6,统计分析各种组间的差异。结果与对照组比较,肺部感染组PCT、HBP和IL-6水平显著升高,差异有统计学意义(P<0.05);与对照组比较,重症肺炎组PCT、HBP和IL-6水平显著升高,差异有统计学意义(P<0.05);与普通肺炎组比较,重症肺炎组PCT、HBP和IL-6水平显著升高,差异有统计学意义(P<0.05)。结论血浆PCT、HBP和IL-6对肺部炎症患者进展为重症肺炎有早期预判的临床价值,为急诊将进展为重症肺炎患者的诊断提供早期预判,便于临床及时干预,让患者及时得到规范救治和准确用药。Objective To investigate the clinical significance of plasma procalcitonin(PCT),heparin-binding protein(HBP)and interleukin-6(IL-6)in predicting the progression of pneumonia to severe disease in the early stage.Methods Eighty six cases of pneumonia treated in this hospital from June 1,2019 to February 23,2022 were selected as the research objects,and the patients were divided into 42 cases of ordinary pneumonia group and 44 cases of severe pneumonia group,and 50 cases of health examination patients of this hospital were selected as the control group at the same time.Plasma HPP levels were detected by chemiluminescence and serum HPP levels were detected by immunofluorescence,plasma procalcitonin,heparin-binding protein and interleukin-6 were compared in the control group and pneumonia group,plasma calcitoninogen,heparin-binding protein and interleukin-6 were compared in the control group and severe pneumonia group,and plasma procalcitonin,heparin-binding protein and interleukin-6 were compared in the general pneumonia group and severe pneumonia group.Results PCT,HBP and IL-6 levels were significantly increased in the pulmonary infection group compared with the control group,the difference was statistically significant(P<0.05),PCT,HBP and IL-6 levels were significantly increased in the severe pneumonia group compared with the control group,the difference was statistically significant(P<0.05),and PCT,HBP and IL-6 levels were significantly increased in the severe pneumonia group compared with the general pneumonia group,the difference was statistically significant(P<0.05).Conclusion Plasma procalcitonin,heparin-binding protein and interleukin-6 have early pre-judgment clinical value for the progression of severe pneumonia in patients with lung inflammation,and provide early prediction for the diagnosis of patients with severe pneumonia in the emergency department,so that patients can receive timely and standardized treatment and accurate medication.

关 键 词：肺炎 重症肺炎 肝素结合蛋白 血浆降钙素原 白细胞介素-6 早期预判 

分 类 号：R563.1[医药卫生—呼吸系统]