Hippo通路在动物组织发育中的调控作用研究进展  

Research Progress of the Regulation of Hippo Pathway in Animal Tissue Development

作　　者：朱建国 刘廷武[2] 季海波[3] 龚道清[1] 刘颖 谢鹏[2] ZHU Jianguo;LIU Tingwu;JI Haibo;GONG Daoqing;LIU Ying;XIE Peng(School of Animal Science and Technology,Yangzhou University,Jiangsu Yangzhou 225125,China;College of Life Sciences,Huaiyin Normal University,Jiangsu Huai’an 223001,China;Huai’an Zhengchang Feed Co.,Ltd,Jiangsu Huai’an 223001,China)

机构地区：[1]扬州大学动物科学与技术学院,江苏扬州225125 [2]淮阴师范学院生命科学学院,江苏淮安223001 [3]淮安正昌饲料有限公司,江苏淮安223001

出　　处：《中国畜牧杂志》2023年第6期18-26,35,共10页Chinese Journal of Animal Science

基　　金：国家自然科学基金(31501974、31902127)。

摘　　要：Hippo信号通路是一条新近发现的信号传导途径,由多种抑癌和原癌基因组成,并与其他信号通路存在交联,其生物学效应主要是通过抑制细胞增殖进而调控动物组织、器官体积大小以及保持内环境稳定等。本文综述了Hippo信号通路的特性及其在动物多种组织发育过程中的调控作用,以期对指导动物生产和遗传改良以及开展相关的生理学研究提供参考。Hippo signaling pathway is a newly discovered signal transduction pathway,which is composed of a variety of tumor suppressor and proto-oncogenes,and is cross-linked with other signaling pathways.Its biological effect is mainly by inhibiting cell proliferation and regulating animal tissue and organ size and maintaining internal environment stability.This paper discusses the characteristics of Hippo signaling pathway and its regulatory role in the development of various tissues in animals,in order to provide reference for guiding animal production,genetic improvement and related physiological research.

关 键 词：Hippo信号通路 细胞增殖 组织再生 

分 类 号：S813.1[农业科学—畜牧学]