有机溶质转运体α-β在动物胆汁酸代谢中的作用  

The Role of the Organic Solute Transporterα-βin Bile Acid Metabolism in Animals

作　　者：尚隆华 黎力之 幸清凤 关玮琨 廖晓鹏 张海波[1] 郭冬生[1] 彭赟 SHANG Longhua;LI Lizhi;XING Qingfeng;GUAN Weikun;LIAO Xiaopeng;ZHANG Haibo;GUO Dongsheng;PENG Yun(College of Life Science and Resources and Environment,Yichun University,Jiangxi Yichun 336000,China)

机构地区：[1]宜春学院生命科学与资源环境学院,江西宜春336000

出　　处：《中国畜牧杂志》2023年第6期36-40,共5页Chinese Journal of Animal Science

基　　金：国家地区科学基金(32060773、32160804);江西省自然科学基金(20202BABL205010);江西省教育厅项目(GJJ 190848、GJJ201621)。

摘　　要：有机溶质转运体α-β(OSTα-OSTβ)是影响胆汁酸代谢的关键因子之一,其主要通过转运胆汁酸,活化法尼醇X受体(FXR),激活胆固醇7α-羟化酶(CYP7A1)途径,调控胆汁酸合成量。且OSTα-OSTβ表达缺失时,胆汁酸合成减少,脂质吸收率降低,对胰岛素信号传导的损伤减轻,维持胰岛素敏感性,改善机体健康状况。本文就OSTα-OSTβ对动物胆汁酸的调控作用进行综述,旨在为OSTα-OSTβ在畜牧生产中的应用提供参考。Organic solute transporterα-β(OSTα-OSTβ)is one of the key factors that affects bile acid metabolism an d activates farnesoid X receptor(FXR)and cholesterol 7α-hydroxylase(CYP7A1)pathways by transporting bile acid and regulating the quantity of bile acid synthesis.When OSTα-OSTβexpression is lost,the synthesis of bile acids and the absorption rate of lipids is reduced,and the damage of insulin signal transduction is reduced,maintaining insulin sensitivity and improving the body health status.This paper focuses on elaborating on the regulatory effect on bile acid of OSTα-OSTβin animals,intending to provide reference for the application of OSTα-OSTβin animal production.

关 键 词：有机溶质转运体α-β 胆汁酸代谢 法尼醇X受体 胆固醇7Α-羟化酶 

分 类 号：S811.2[农业科学—畜牧学]