孕晚期B族链球菌感染及绒毛膜羊膜炎对低出生体重儿的交互作用  

Interaction of B-group streptococcal infection and chorioamnionitis in low birth weight infants during late pregnancy

作　　者：刘志奎[1] 冯亚娟[1] 成岚[1] Liu Zhikui;Feng Yajuan;Cheng Lan(Department of Obstetrics and Gynecology,Taizhou Second People′s Hospital,Taizhou 225500,China)

机构地区：[1]泰州市第二人民医院妇产科,泰州225500

出　　处：《中国医师杂志》2023年第5期734-738,共5页Journal of Chinese Physician

摘　　要：目的探究孕晚期B族链球菌感染及绒毛膜羊膜炎(CAM)对低出生体重儿(LBWI)的交互作用。方法回顾性选取2019年10月至2022年4月于泰州市第二人民医院行定期产检并完成分娩的524例产妇,根据其新生儿出生体重分为正常组(466例)与LBWI组(58例),比较两组产妇的年龄、孕次、产次、孕期体重指数(BMI)、剖宫产史、流产史、妊娠期贫血、妊娠期高血压疾病、妊娠期糖尿病、阴道炎、B族链球菌感染、CAM、胎膜早破、产后出血、产褥感染、新生儿早产、新生儿窒息、新生儿感染、胎儿窘迫情况,用logistic回归方法分析LBWI的影响因素,分析B族链球菌感染、CAM对LBWI的相关性与交互作用。结果两组产妇年龄、流产史、妊娠期高血压疾病、阴道炎、B族链球菌感染、CAM、胎膜早破、新生儿早产、新生儿感染、胎儿窘迫情况差异具有统计学意义(均P<0.05)。Logistic回归分析结果显示,妊娠期高血压疾病、B族链球菌感染、CAM、胎膜早破、早产、新生儿感染、胎儿窘迫是LBWI的危险因素(均P<0.05),B族链球菌感染、CAM与LBWI呈正相关(r=0.587、0.604,均P<0.001)。交互作用分析结果显示,B族链球菌感染、CAM与LBWI呈正相关(均P<0.001)。结论孕晚期B族链球菌感染、CAM与LBWI呈正相关,两者共存可增加LBWI风险。Objective To investigate the interaction of B-group streptococcal infection and chorioamnionitis(CAM)with late pregnancy and low birth weight infant(LBWI).Methods A retrospective study was conducted on 524 postpartum women who underwent regular prenatal examinations and completed delivery at the Taizhou Second People′s Hospital from October 2019 to April 2022.According to their newborn birth weight,they were divided into normal group(466 cases)and LBWI group(58 cases).The age,pregnancy times,birth times,pregnancy body mass index(BMI),cesarean section history,abortion history,anemia during pregnancy,hypertensive disorder during pregnancy,diabetes during pregnancy,vaginitis,B-group streptococcal infection,CAM,premature rupture of membranes,postpartum hemorrhage,puerperal infection,neonatal preterm delivery,neonatal asphyxia,neonatal infection,fetal distress were compared between the two groups.The influencing factors of LBWI were analyzed using logistic regression.The correlation and interaction between B-group streptococcal infection and CAM on LBWI were analyzed.Results There was a statistically significant difference in age,history of miscarriage,gestational hypertension,vaginitis,B-group streptococcal infection,CAM,premature rupture of membranes,neonatal preterm birth,neonatal infection and fetal distress between the two groups(all P<0.05).The results of logistic regression analysis showed that gestational hypertension,B-group streptococcal infection,CAM,premature rupture of membranes,preterm birth,neonatal infection,and fetal distress were risk factors for LBWI(all P<0.05).B-group streptococcal infection,CAM,and LBWI were positively correlated(r=0.587,0.604,all P<0.001).The interaction analysis results showed a positive correlation between B-group streptococcal infection,CAM,and LBWI(all P<0.001).Conclusions B-group streptococcal infection in late pregnancy,CAM,and LBWI are positively correlated,and their coexistence can increase the risk of LBWI.

关 键 词：婴儿 出生时低体重 链球菌 B族 绒毛膜羊膜炎 

分 类 号：R722.6[医药卫生—儿科]