卵泡液基质金属蛋白酶-2及其抑制物与多囊卵巢综合征患者妊娠结局的相关性研究  

Study on the correlations between matrix metalloproteinase-2 and its inhibitor in follicular fluid and pregnancy outcome of polycystic ovary syndrome patients

作　　者：李喜梅 林丽 毛郁蕾 张梦思 丁小游 LI Xi-mei;LIN Li;MAO Yu-lei;ZHANG Meng-si;DING Xiao-you(Department of Gynecology and Obstetrics,Wenzhou Central Hospital,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州市中心医院妇产科,浙江温州325000

出　　处：《中国妇幼保健》2023年第11期2014-2017,共4页Maternal and Child Health Care of China

基　　金：浙江省温州市科学技术局项目(Y2020513)。

摘　　要：目的探讨卵泡液基质金属蛋白酶-2(MMP-2)、组织金属蛋白酶抑制因子2(TIMP2)与多囊卵巢综合征(PCOS)患者妊娠结局的相关性。方法选取2020年2月—2021年2月在温州市中心医院行体外受精-胚胎移植(IVF-ET)的PCOS患者50例作为研究组,选取同期50例卵巢功能正常因输卵管因素行IVF-ET的患者为对照组。统计两组妊娠结局,检测其卵泡液MMP-2、TIMP2水平,并采用Pearson相关性分析法分析卵泡液MMP-2、TIMP2和PCOS患者妊娠结局的相关性。结果对照组卵泡液MMP-2、TIMP2水平分别为(35.28±5.58)ng/ml和(46.52±8.48)ng/ml;研究组卵泡液MMP-2、TIMP2水平分别为(57.44±7.22)ng/ml和(31.15±5.04)ng/ml。研究组患者卵泡液MMP-2水平高于对照组,卵泡液TIMP2水平低于对照组(均P<0.05)。研究组早期先兆流产、早产、妊娠期高血压疾病、妊娠期糖尿病及剖宫产等不良妊娠结局发生率均明显高于对照组(均P<0.05)。Pearson相关性分析结果显示:卵泡液MMP-2水平和PCOS患者早期先兆流产、早产、妊娠期高血压疾病、妊娠期糖尿病及剖宫产等不良妊娠结局均呈正相关(r=0.377、0.409、0.474、0.522、0.458,均P<0.05);卵泡液TIMP2水平和PCOS患者早期先兆流产、早产、妊娠期高血压疾病、妊娠期糖尿病及剖宫产等不良妊娠结局均呈负相关(r=-0.669、-0.448、-0.517、-0.422、-0.551,均P<0.05)。结论卵泡液MMP-2、TIMP2与PCOS患者的妊娠结局密切相关,临床应密切监测PCOS患者卵泡液MMP-2、TIMP2水平,为制定预防干预措施提供理论参考。Objective To investigate the correlations between matrix metalloproteinase-2(MMP-2)and its inhibitor(TIMP2)in fllicular fluid and pregnancy outcome of polycystic ovary syndrome(PCOS)patients.Methods Fifty PCOS patients undergoing in vitro fertilization-embryo transfer(IVF-ET)in Wenzhou Central Hospital from February 2020 to February 2021 were selected as study group.At the same time,50 patients with normal ovarian function who underwent IVF-ET due to Fallopian tube factors were selected as control group.The pregnancy outcomes of the two groups were counted,and the levels of MMP-2 and TIMP2 in follicular fluid were detected,and the correlations between MMP-2 and TIMP2 in follicular fluidin and pregnancy outcome of PCOS patients were analyzed by Pearson correlation analysis method.Results The levels of MMP-2 and TIMP2 in control group were(35.28±5.58)ng/ml and(46.52±8.48)ng/ml,respectively;the levels of MMP-2 and TIMP2 in study group were(57.44±7.22)ng/ml and(31.15±5.04)ng/ml,respectively.The level of MMP-2 in follicular fluid of study group was higher than that of control group,and the level of TIMP2 in follicular fluid of study group was lower than that of control group(P<0.05):The incidence rates of adverse pregnancy outcomes,such as early threatened abortion,premature delivery,hypertension during pregnancy,gestational diabetes mellitus,and cesarean section,in study group were significantly higher than those in control group(P<0.05).Pearson correlation analysis showed that the level of MMP-2 in follicular fluid was positively correlated with adverse pregnancy outcomes in PCOS patients,such as early threatened abortion,preterm delivery,hypertension during pregnancy,gestational diabetes mellitus,and cesarean section(r=0.377,0.409,0.474,0.522,0.458,all P<0.05);the level of TIMP2 in follicular fluid was negatively correlated with adverse pregnancy outcome in PCOS patients,such as early threatened abortion,preterm delivery,hypertension during pregnancy,gestational diabetes mellitus,and cesarean section(r=-0.669,-

关 键 词：基质金属蛋白酶-2 组织金属蛋白酶抑制因子2 多囊卵巢综合征 妊娠结局 相关性 

分 类 号：R711.75[医药卫生—妇产科学]