疏肝和胃止痛方治疗肝胃不和慢性胃炎伴幽门螺杆菌感染疗效观察  

Curative effects of Shugan Hewei Zhitong Recipe on chronic gastritis complicated by Helicobacter pylori infection

作　　者：刘美华[1] 杨蓓[1] 郝若飞[2] 金宇安[3] Liu Meihua;Yang Bei;Hao Ruofei;Jin Yu'an(Department of Traditional Chinese Internal Medicine,Huguosi Hospital of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100035,China;Department of Laboratory Medicine,Huguosi Hospital of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100035,China;Specialist Clinic,Huguosi Hospital of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100035,China)

机构地区：[1]北京中医药大学附属护国寺中医医院中医内科,北京100035 [2]北京中医药大学附属护国寺中医医院检验科,北京100035 [3]北京中医药大学附属护国寺中医医院专家门诊,北京100035

出　　处：《中国基层医药》2023年第5期646-650,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：北京中医药薪火传承“3+3”工程金宇安基层老中医传承工作室建设项目 (2013-JC-16)。

摘　　要：目的观察疏肝和胃止痛方治疗肝胃不和慢性胃炎伴幽门螺杆菌感染的疗效。方法选取北京中医药大学附属护国寺中医医院2018年7月至2020年6月治疗的肝胃不和慢性胃炎伴幽门螺杆菌感染患者87例,采用随机数字表法分为观察组44例和对照组43例。对照组给予常规西药治疗,观察组在对照组的基础上给予疏肝和胃止痛方治疗,疗程2周。比较两组治疗前后中医证候积分改善情况,进行疗效评定。结果观察组总有效率为91%(40/44),显著高于对照组的72%(31/43),差异有统计学意义(χ^(2)=5.13,P=0.024)。治疗后,两组患者中医证侯积分均较治疗前明显降低(均P<0.001),且观察组证候积分相比于对照组显著降低(P<0.05)。两组患者均无不良反应发生。结论疏肝和胃止痛方治疗肝胃不和慢性胃炎伴幽门螺杆菌感染疗效确切且安全,值得临床推广。Objective To investigate the curative effects of Shugan Hewei Zhitong Recipe on chronic gastritis complicated by Helicobacter pylori infection.Methods Eighty-seven patients with chronic gastritis complicated by Helicobacter pylori infection who received treatment in the Huguosi Hospital of Traditional Chinese Medicine,Beijing University of Chinese Medicine,China from July 2018 to June 2020 were included in this study.They were randomly assigned to undergo treatment with either conventional Western medicine(n=43,control group)or Shugan Hewei Zhitong Recipe based on conventional Western medicine(n=44,observation group)for 2 weeks.Before and after treatment,traditional Chinese medicine syndrome scores were compared between the two groups.Curative effects of Shugan Hewei Zhitong Recipe on chronic gastritis complicated by Helicobacter pylori infection were evaluated.Results Total response rate in the observation group was significantly higher than that in the control group[91%(40/44)vs.72%(31/43),χ^(2)=5.13,P=0.024].In each group,the traditional Chinese medicine symptom score post-treatment was significantly lower than the traditional Chinese medicine symptom score pre-treatment(both P<0.001).After treatment,the traditional Chinese medicine score of the observation group was significantly lower than that of the control group(P<0.05).There were no adverse reactions in each group.Conclusion Shugan Hewei Zhitong Recipe is safe and effective on chronic gastritis complicated by Helicobacter pylori infection,which is worthy of clinical promotion.

关 键 词：胃炎 幽门螺杆菌 肝胃不和证 疏肝和胃止痛方 临床对照试验 

分 类 号：R259[医药卫生—中西医结合]