联合检测血人绒毛膜促性腺激素、孕酮、雌二醇及B超对早期宫内妊娠结局的预测价值研究  

Study on the predictive value of serum β-human chorionic gonadotropin,progesterone and estradiol combined with B-ultrasound in predicting early intrauterine pregnancy outcomes

作　　者：耿媛媛 李燕[2] 郭伟 孙屹梅 GENG Yuanyuan;LI Yan;GUO Wei;SUN Yimei(The First Department of Obstetrics,Hengshui Second People's Hospital,Hengshui 053000,Hebei,China;Department of Gynecology,Hengshui Second People's Hospital,Hengshui 053000,Hebei,China)

机构地区：[1]衡水市第二人民医院产一科,河北衡水053000 [2]衡水市第二人民医院妇科,河北衡水053000

出　　处：《中国性科学》2023年第6期104-108,共5页Chinese Journal of Human Sexuality

基　　金：衡水市科技计划项目(2020014042Z)。

摘　　要：目的探究血人绒毛膜促性腺激素(β-HCG)、孕酮(P)、雌二醇(E_(2))联合B超对早期宫内妊娠结局预测价值。方法选取2018年6月至2020年6月在衡水市第二人民医院产科进行孕检的320例孕早期孕妇作为研究对象。根据早期宫内妊娠结局将正常妊娠及胚胎停育孕妇分为对照组(n=210)与研究组(n=110),依据孕妇入组时孕周将5~6^(+6)周、7~8^(+6)周、9~11^(+6)周孕妇分为对照A组(n=64)、对照B组(n=71)、对照C组(n=75)与研究A组(n=36)、研究B组(n=31)、研究C组(n=43)。所有孕妇均行腹部B超及血β-HCG、P、E2水平测定,分析各指标联合对早期宫内妊娠结局的预测价值。结果研究组5~6^(+6)周、7~8^(+6)周、9~11^(+6)周子宫动脉阻力指数(PI)、搏动指数(RI)水平高于对应孕周对照组,而β-HCG、P、E2水平低于对应孕周对照组(P<0.05);受试者工作特征曲线显示,5~6^(+6)周时PI、RI、β-HCG、P、E2及各指标联合预测早期宫内妊娠结局曲线下面积(AUC)分别为0.609、0.590、0.651、0.647、0.670、0.790;7~8^(+6)周时AUC分别为0.623、0.671、0.701、0.666、0.761、0.883;9~11^(+6)周时AUC分别为0.728、0.720、0.855、0.669、0.720、0.930。结论血β-HCG、P、E2联合B超测定血流参数有助于提高对早期宫内妊娠结局预测价值。Objective To investigate the predictive value of serumβ-human chorionic gonadotropin(β-HCG),progesterone(P)and estradiol(E_(2))combined with B-ultrasound in predicting early intrauterine pregnancy outcomes.Methods A total of 320 pregnant women in early pregnancy who received antenatal care in Department of Obtetrics of Hengshui Second People's Hospital from June 2018 to June 2020 were selected as the research subjects.Pregnant women with normal pregnancy and those with abortive embryo were defined as the control group(n=210)and the study group(n=110),respectively.According to gestational age,pregnant women with gestational age of 5-6+6 weeks,7-8+6 weeks and 9-11+6 weeks were included into the control group A(n=64),the control group B(n=71),the control group C(n=75),the study group A(n=36),the study group B(n=31)and the study group C(n=43).All pregnant women underwent abdominal B-ultrasound examination and were tested for serumβ-HCG,P and E.The predictive value of the combination of these indicators for early intrauterine pregnancy outcomes was analyzed.Results Uterine artery pulsatile index(PI)and resistance index(RI)were higher,and the levels ofβ-HCG,P and E,were lower in the three study groups than in the three control groups(P<0.05).The receiver operating characteristic curves showed that at 5-6^(+6)weeks,7-8^(+6)weeks and 9-11^(+6)weeks,the area under the curve(AUC)values of PI,RI,β-HCG,P,E_(2)alone and in combination to predict early intrauterine pregnancy outcomes were(0.609,0.590,0.651,0.647,0.670,0.790),(0.623,0.671,0.701,0.666,0.761,0.883)and(0.728,0.720,0.855,0.669,0.720,0.930),respectively.Conclusions Serumβ-HCG,P and E_(2)combined with blood flow parameters measured by B-ultrasound can improve the prediction value of early intrauterine pregnancy outcomes.

关 键 词：人绒毛膜促性腺激素 孕酮 雌二醇 B超 宫内妊娠 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]