妊娠高血压产妇尿β2-MG、TRF水平与早期肾损伤及不良妊娠结局的相关性分析  

Analysis of correlation between urinaryβ2-MG,TRF levels and early renal inyury,adverse pregnancy outcomes in parturients with gestational hypertension

作　　者：冯怡凡 FENG Yifan(Luoyang Dongfang People′s Hospital/the Third Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]洛阳市东方人民医院/河南科技大学第三附属医院,河南洛阳471000

出　　处：《华夏医学》2023年第2期66-70,共5页Acta Medicinae Sinica

摘　　要：目的:探讨妊娠高血压产妇尿β2微球蛋白(β2-MG)、转铁蛋白(TRF)水平变化与早期肾损伤及不良妊娠结局的关系。方法:选取妊娠高血压产妇72例,比较有无肾损伤及不同妊娠结局产妇β2-MG、TRF水平差异,分析β2-MG、TRF水平与妊娠高血压产妇早期肾损伤、不良妊娠结局的相关性,并分析尿β2-MG、TRF水平对妊娠高血压产妇早期肾损伤及不良妊娠结局的预测效能。结果:Logistic分析结果显示,β2-MG、TRF与妊娠高血压产妇早期肾损伤、不良妊娠结局均呈正相关性(P<0.05);β2-MG、TRF预测妊娠高血压产妇早期肾损伤的AUC分别为0.763、0.714,预测妊娠高血压产妇不良妊娠结局的AUC分别为0.715、0.710。结论:β2-MG、TRF水平可作为预测妊娠高血压产妇早期肾损伤、不良妊娠结局的有效指标,具有一定的临床应用价值。Objective:To investigate the relationship between changes in urinaryβ-2 microglobulin(β2-MG)and transferrin(TRF)levels and early renal injury,and adverse pregnancy outcomes in parturients with gestational hypertension.Methods:72 parturients with gestational hypertension were selected to compare whether there was kidney injury or not and the difference ofβ2-MG and TRF levels in parturients with different pregnancy outcomes,and to analyze the correlation betweenβ2-MG and TRF levels and early kidney injury and adverse pregnancy outcomes.In addition,the predictive efficacy of urinaryβ2-MG and TRF levels on early renal injury and adverse pregnancy outcomes in gestational hypertension parturients was analyzed.Results:Logistic analysis showed thatβ2-MG and TRF levels were positively correlated with early kidney injury and adverse pregnancy outcomes in parturients with gestational hypertension(P<0.05).In parturients with gestational hypertension,the AUC values ofβ2-MG and TRF for predicting early kidney injury were 0.763 and 0.714,respectively,and the AUC values for predicting adverse pregnancy outcome were 0.715 and 0.710,respectively.Conclusion:β2-MG and TRF levels can be used as effective indicators to predict early kidney injury and adverse pregnancy outcome in parturients with gestational hypertension,which have certain clinical application value.

关 键 词：妊娠高血压 尿Β2微球蛋白 转铁蛋白 早期肾损伤 不良妊娠结局 

分 类 号：R719.3[医药卫生—妇产科学]