超脉冲二氧化碳点阵激光联合常规用药治疗慢性湿疹的效果  

Effects of ultra-pulsed carbon dioxide fractional laser combined with conventional medication in the treatment of chronic eczema

作　　者：李玉蕊 陈萍 LI Yurui;CHEN Ping(Dept.of Dermatology,Nanyang Zhang Zhongjing Hospital,Nanyang 473000,China)

机构地区：[1]南阳张仲景医院皮肤科,河南南阳473000

出　　处：《华夏医学》2023年第2期125-129,共5页Acta Medicinae Sinica

摘　　要：目的:探讨超脉冲二氧化碳点阵激光联合复方氟米松软膏、复方甘草酸苷片治疗慢性湿疹的效果。方法:选取94例慢性湿疹患者,根据治疗方案不同分为常规组和研究组,每组各47例。常规组给予复方氟米松软膏和复方甘草酸苷片治疗,研究组在常规组基础上联合超脉冲二氧化碳点阵激光。比较两组疗效、临床症状积分、病情相关指标、炎性因子水平、不良反应情况、生活质量。结果:研究组总有效率高于常规组,两组比较差异有统计学意义(P<0.05);治疗后,研究组皲裂、DLQI、瘙痒、丘疹、红斑评分低于常规组(P<0.05);治疗后,研究组IL-4、CRP、TNF-α、ICAM-1、VCAM-1低于常规组,IFN-γ高于常规组(P<0.05);不良反应总发生率组间比较无统计学差异(P>0.05)。结论:超脉冲二氧化碳点阵激光联合复方氟米松软膏、复方甘草酸苷片治疗可有效缓解慢性湿疹患者临床症状,改善免疫功能。Objective:To investigate the effect of ultra-pulsed carbon dioxide fractional laser combined with compound flumetasone ointment and compound glycyrrhizin tablets in the treatment of chronic eczema.Methods:94 patients with chronic eczema were divided into the routine group(n=47)and study group(n=47)according to different treatment regimens.The routine group were treated with compourd flumetasone ointment and compourd glycyrrhixhin tablets,while the study group were given ultra-pulsed carbon dioxide fractional laser therapy on the basis of the routine group.The curative effect,clinical symptom scores,disease-related indicators,inflammatory factor levels,adverse reactions,and quality of life were compared between the two groups.Results:The total effective rate of the study group was higher than of the routine group,with a statistically significant difference(P<0.05).After treatment,the scores of chapped,DLQI,pruritus,papule and erythema in the study group were lower than those of the routine group(P<0.05).After treatment,in the study group,IL-4,CRP,TNF-α,ICAM-1,VCAM-1 were lower than those of the routine group,and IFN-γwas higher than those of the routine group(P<0.05).The total incidence of adverse reactions was no significant difference between the groups(P>0.05).Conclusion:Ultra-pulsed carbon dioxide fractional laser combined with compound flurnetasone and compourd glycyrrhizin tablets can effectively relieve clinical symptoms and improve immune function in patients with chronic eczema.

关 键 词：超脉冲二氧化碳点阵激光 慢性湿疹 复方氟米松软膏 复方甘草酸苷片 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]