苗药血人参化学成分和药理作用研究进展及Q-marker的预测分析  

Research Progress on Chemical Constituents and Pharmacological Effects of Indigofera stachyoides Lindl.and Predictive Analysis of Q-marker

作　　者：廖泽宇 傅建 付慧晓 何鑫 徐剑 吴静澜 张永萍 LIAO Zeyu;FU Jian;FU Huixiao;HE Xin;XU Jian;WU Jinglan;ZHAGN Yongping(School of Pharmacy,Guizhou University of Traditional Chinese Medicine/National Miao Medicine Engineering Technology Research Center/Guizhou Traditional Chinese Medicine Processing and Preparation Engineering Technology Research Center,Guiyang 550025,China;The First People s Hospital of Guiyang City,Guiyang 550002,China)

机构地区：[1]贵州中医药大学药学院/国家苗药工程技术研究中心/贵州中药炮制与制剂工程技术研究中心,贵州贵阳550025 [2]贵阳市第一人民医院,贵州贵阳550002

出　　处：《中国民族民间医药》2023年第12期37-47,共11页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然科学联合项目基金(No.U1812403);国家自然科学基金青年科学基金项目(No.81903517);贵州省科技计划项目(No.黔科合基础[2020]1Y371,No.黔科合支撑[2021]一般411);贵阳市高层次创新性青年科技人才(筑科合同[2021]43-10号);贵州省(第六批)高层次创新型人才(“千”层次)。

摘　　要：血人参(Indigofera stachyoides Lindl.)作为我国苗族传统用药,主要分布于贵州、云南、广西等地区。血人参的主要化学成分包括黄酮类、糖苷类、甾醇类、萜类、酚酸类以及挥发油类等,其药理作用有保肝、抑菌、降血糖、降血脂、抗肿瘤、抗氧化及抗炎等。文章对血人参的化学成分和药理作用的研究进行归纳与总结,并结合Q-marker概念,从植物亲缘学、化学成分特有性、传统功效和药性、现代临床新用途、化学成分可测性等几个方面对其进行Q-marker预测分析。根据Q-marker的概念,可将木脂素糖苷类成分血人参苷、Schizandriside、Lyoniside和血人参鞣质A作为血人参的Q-marker,将黄酮类作为其备选物质。Indigofera stachyoides Lindl.is a traditional medicine of the Miao nationality in China,it is mainly distributed in Guizhou,Yunnan,Guangxi and other regions.It contains a variety of chemical components,includingsterols,terpenoids,phenolic acids,volatile oilsand other components,with liver protection,anti-tumor,hypoglycemic properties,blood lipid lowering,antibacterial,anti-oxidation,anti-inflammatory and other broad pharmacological activities.Herein,we summarized the research on the chemical components and pharmacological effects of Indigofera stachyoides Lindl.and combined the Q-marker concept,from plant phylogeny,specificity of chemical components,traditional efficacy and medicinal properties,modern clinical new uses,and measurability of chemical components Q-marker predictive analysis is carried out in several aspects.According to the concept of Q-marker,9-O-acetyl-9′-O-β-D-xylopyranoside,Schizandriside,Lyoniside andStachyotannin A can be used as Q-markers of Indigofera stachyoides Lindl.,and flavonoids can be used as alternative substances.

关 键 词：血人参 化学成分 药理作用 质量标志物 

分 类 号：R285.5[医药卫生—中药学]