HIV感染患者血清白细胞介素与淋巴细胞水平的关系  

Correlation between serum interleukins and lymphocyte levels in HIV-infected patients

作　　者：韩阳[1] 叶卫丰[1] 侯振宇 朱青 韩强 HAN Yang;YE Weifeng;HOU Zhenyu(Department of Laboratory Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院检验科,北京市100050

出　　处：《河北医药》2023年第10期1522-1525,共4页Hebei Medical Journal

基　　金：首都医科大学附属北京友谊医院“友谊种子计划”人才项目(编号:YYZZ202138)。

摘　　要：目的观察人类免疫缺陷病毒(HIV)感染患者血清白细胞介素、淋巴细胞水平,并分析其关系。方法回顾性分析2019年3月至2022年7月医院收治的128例HIV感染患者临床资料,所有患者治疗前接受血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)检测及CD4^(+)、CD8^(+)T淋巴细胞水平检测,分析IL-1β、IL-6、IL-10与CD4^(+)、CD8^(+)T淋巴细胞水平的关系。结果128例HIV感染患者IL-1β、IL-6、IL-10、CD4^(+)、CD8^(+)水平分别为(2.92±1.04)pg/ml、(4.36±1.56)pg/ml、(3.62±1.13)pg/ml、(416.41±68.59)个/ml、(1418.93±94.18)个/ml;病毒载量<40 copies/ml的HIV感染患者CD4^(+)、CD8^(+)水平高于病毒载量40~103copies/ml及>103copies/ml的患者,有吸烟史的HIV感染患者CD8^(+)水平,差异有统计学意义(P<0.05);经Pearson相关性分析,HIV感染患者血清IL-1β、IL-6、IL-10水平与CD4^(+)及CD8^(+)呈负相关(r值分别为-0.552、-0.421、-0.440、-0.404、-0.556、-0.420,P<0.05);经Kendall’stau-b相关性分析,结果显示,病毒载量与HIV感染患者CD4^(+)、CD8^(+)水平呈负相关(r值分别为-0.292、-0.241,P>0.05);经点二列相关性分析,结果显示,吸烟史与HIV感染患者CD4^(+)、CD8^(+)水平呈负相关(r值分别为-0.417、-0.499,P>0.05)。结论HIV感染患者血清IL-1β、IL-6、IL-10水平与CD4^(+)、CD8^(+)水平密切相关。Objective To measure serum interleukins and lymphocyte levels in human immunodeficiency virus(HIV)-infected patients and to analyze their correlation.Methods The clinical data of 128 HIV-infected patients admitted to the hospital from March 2019 to July 2022 were analyzed retrospectively.Serum levels of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10)and CD4^(+),CD8^(+)T lymphocyte levels before treatment were measured.The correlation between serum interleukins(IL-1β,IL-6 and IL-10)and lymphocyte levels(CD4+and CD8+T lymphocytes)was analyzed.Results Serum levels of IL-1β,IL-6,IL-10,CD4^(+)and CD8^(+)T lymphocytes in 128 HIV-infected patients were(2.92±1.04)pg/ml,(4.36±1.56)pg/ml,(3.62±1.13)pg/ml,(416.41±68.59)piecse/μl and(1,418.93±94.18)piecse/μl,respectively.CD4^(+)and CD8^(+)T lymphocyte levels in HIV-infected patients with viral load<40 copies/ml were significantly higher than those with viral load 40-103 copies/ml and>103 copies/ml.There was a significant difference in the CD8^(+)T lymphocyte level between HIV-infected either with smoking history or not(P<0.05).Pearson correlation analysis showed that serum levels of IL-1β,IL-6 and IL-10 in HIV-infected patients were negatively correlated with CD4^(+)and CD8^(+)T lymphocyte levels(r values were-0.552,-0.421,-0.440,-0.404,-0.556,-0.420,P<0.05).Kendall’s tau-b correlation analysis showed that the viral load was negatively correlated with CD4^(+)and CD8^(+)T lymphocyte levels in HIV-infected patients(r values were-0.292,-0.241,P>0.05).The point-biserial correlation analysis showed that smoking history was negatively correlated with CD4^(+)and CD8^(+)T lymphocyte levels in HIV-infected patients(r values were-0.417,-0.499,P>0.05).Conclusion Serum levels of IL-1β,IL-6 and IL-10 are closely correlated with CD4^(+)and CD8^(+)T lymphocyte levels in HIV-infected patients.

关 键 词：艾滋病毒感染 白细胞介素 淋巴细胞 

分 类 号：R512.91[医药卫生—内科学]