Modeling human neurodevelopmental diseases with brain organoids  

作　　者：Xiaoxiang Lu Jiajie Yang Yangfei Xiang 

机构地区：[1]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Cell Regeneration》2022年第1期1-13,共13页细胞再生（英文）

基　　金：This work was supported by the Shanghai Pujiang Program(20PJ1410400);National Natural Science Foundation of China(32170836);the ShanghaiTech University start-up fund。

摘　　要：Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain’s complexity and its limited accessibility.Human pluripotent stem cells(hPSCs)-derived brain organoids are capable of recapitulating various features and functionalities of the human brain,allowing the investigation of intricate patho-genesis of developmental abnormalities.Over the past years,brain organoids have facilitated identifying disease-associated phenotypes and underlying mechanisms for human neurodevelopmental diseases.Integrating with more cutting-edge technologies,particularly gene editing,brain organoids further empower human disease modeling.Here,we review the latest progress in modeling human neurodevelopmental disorders with brain organoids.

关 键 词：Brain organoids Neurodevepmental diseases Disease modeling Stem cells Gene editing 

分 类 号：R318[医药卫生—生物医学工程]