High-resolution single-cell analysis paves the cellular path for brain regeneration in salamanders  

作　　者：Binxu Yin Xinyun Li Gufa Lin Heng Wang 

机构地区：[1]College of Animal Science and Technology,Huazhong Agricultural University,Wuhan,China [2]Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education,Orthopaedic Department of Tongji Hospital,School of Life Sciences and Technology,Tongji University,Shanghai,China

出　　处：《Cell Regeneration》2022年第1期389-391,共3页细胞再生（英文）

基　　金：This work is supported by the National Key R&D Program of China(2021YFF1000601,2021YFA0805000);the National Natural Science Foundation of China(31970778);the Natural Science Foundation of Hubei Province(2020CFA006).

摘　　要：Salamanders are excellent models for studying vertebrate brain regeneration,with the promise of developing novel therapies for human brain lesions.Yet the molecular and cellular mechanism of salamander brain regeneration remains largely elusive.The insight into the evolution of complex brain structures that lead to advanced functions in the mammalian brain is also inadequate.With high-resolution single-cell RNA sequencing and spatial transcriptomics,three recent studies have reported the differentiation paths of cells in the salamander telencephalon in the journal Science,bringing both old and new cell types into the focus and shedding light on vertebrate brain evolution,devel-opment,and regeneration.

关 键 词：RESOLUTION bringing journal 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]