E组慢性阻塞性肺疾病患者血嗜酸性粒细胞计数临床意义分析  

Clinical significance of blood eosinophil count in group E patients with chronic obstructive pulmonary disease

作　　者：李文雅[1] 邹外龙[1] LI Wenya;ZOU Wailong(Department of Respiratory and Critical Care Medicine,Aerospace Central Hospital,Beijing 100049,China)

机构地区：[1]航天中心医院呼吸与危重症医学科,北京100049

出　　处：《中国当代医药》2023年第17期20-23,共4页China Modern Medicine

摘　　要：目的探讨血嗜酸性细胞(BE)在评估E组慢性阻塞性肺疾病患者病情中的临床意义。方法回顾性分析2020年1月至2020年12月在航天中心医院呼吸与危重症医学科住院的151例E组慢性阻塞性肺疾病患者的临床资料,其中女59例,男92例,平均(65.1±10.2)岁,收集患者入院时一般资料、BE值及肺功能等相关指标。1年后随访肺功能的相关指标,根据BE是否≤100 cells/μl分为BEC≤100 cells/μl(BEC≤100)组以及BEC>100 cells/μl(BEC_(100+))组,BEC≤100组患者98例,BEC_(100+)组53例,比较两组患者的基线临床特征和随访1年内急性加重的次数、肺功能下降程度。结果BEC_(100+)组患者的女性比例、吸烟率高于BEC≤100组,儿童时期哮喘率低于BEC≤100组,差异有统计学意义(P<0.05);BEC_(100+)组肺总量增加值低于BEC≤100组,差异有统计学意义(P<0.05)。剔除两组患者年龄、性别、吸烟率、儿童时期哮喘率以及肺功能等差异,随访1年后,BEC_(100+)组急性加重次数少于BEC≤100组,差异有统计学意义(P<0.05);BEC_(100+)组第1秒钟用力呼气容积(FEV1)下降值低于BEC≤100组,差异有统计学意义(P<0.05)。结论两组患者基线特征和1年后临床结局方面存在差异,血嗜酸性粒细胞计数可以评估E组慢性阻塞性肺疾病患者病情,在疾病预后中有一定的临床意义。Objective To explore the clinical significance of blood eosinophil(BE)in evaluating the condition of patients with chronic obstructive pulmonary disease in group E.Methods A retrospective analysis was conducted on the clinical data of 151 patients with chronic obstructive pulmonary disease in group E who were hospitalized in the Department of Respiratory and Critical Care Medicine of Aerospace Central Hospital from January 2020 to December 2020.Among them,59 were female and 92 were male,with an average age of(65.1±10.2)years.General information,BE values,and lung function related indicators were collected at the time of admission.Lung function related indicators were followed up one year later,according to whether BE≤100 cells/μl,they were divided into the BEC≤100 cells/μl(BEC≤100)group and the BEC>100 cells/μl(BEC_(100+))group.There were 98 patients in the BEC≤100 group and 53 patients in the BEC_(100+)group.The baseline clinical characteristics,the number of acute exacerbations within the following year,and the degree of pulmonary function decline were compared between the two groups.Results The proportion of women and smoking rates in the BEC_(100+)group were higher than those in the BEC≤100 group,and the childhood asthma rate was lower than that in the BEC≤100 group,the differences were statistically significant(P<0.05).The increase in total lung volume in the BEC_(100+)group was lower than that in the BEC≤100 group,with statistically significant difference(P<0.05).Excluding differences in age,gender,smoking rate,childhood asthma rate and lung function between the two groups,after one year of follow-up,the number of acute exacerbations in the BEC_(100+)group was lower than that in the BEC≤100 group,with statistically significant difference(P<0.05).The forced expiratory volume in one second(FEV1)decrease in the BEC_(100+)group was lower than that in the BEC≤100 group,with statistically significant difference(P<0.05).Conclusion There are differences in baseline characteristics and clinical

关 键 词：慢性阻塞性肺疾病 血嗜酸性粒细胞计数 肺功能检查 预后 

分 类 号：R563.9[医药卫生—呼吸系统]