麻杏石甘汤加减联合经鼻高流量湿化氧疗治疗肺炎Ⅰ型呼吸衰竭临床评价  

Clinical Evaluation of Modified Maxing Shigan Decoction Combined with High-Flow Nasal Cannula Oxygen Therapy in the Treatment of Pneumonia Complicated with TypeⅠRespiratory Failure

作　　者：孔繁华[1] 张雪倩 刘疆生 王妹青 赵飞 林涛[1] 张天涛[1] 宋玉勤[1] 李晓旭 杨会杰 KONG Fanhua;ZHANG Xueqian;LIU Jiangsheng;WANG Meiqing;ZHAO Fei;LIN Tao;ZHANG Tiantao;SONG Yuqin;LI Xiaoxu;YANG Huijie(Handan Mingren Hospital,Handan,Hebei,China 056006)

机构地区：[1]邯郸明仁医院,河北邯郸056006

出　　处：《中国药业》2023年第12期105-108,共4页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2021474]。

摘　　要：目的探讨麻杏石甘汤加减联合经鼻高流量湿化氧疗治疗肺炎Ⅰ型呼吸衰竭的临床疗效。方法选取医院2021年1月至2022年5月收治的肺炎Ⅰ型呼吸衰竭住院患者120例,采用电脑系统随机抽签法分为对照组和观察组,各60例。两组患者均予常规治疗及经鼻高流量湿化氧疗,观察组患者加用麻杏石甘汤加减治疗。两组均以1周为1个疗程,共治疗3个疗程。结果观察组总有效率为91.67%,明显高于对照组的75.00%(P<0.05)。治疗后,两组患者的潮气量、肺活量、最大呼气流速、肺总量均明显升高,动脉血氧分压、动脉血氧饱和度、氧合指数均明显升高,动脉血二氧化碳分压明显降低,肺炎严重指数量表、社区获得性肺炎量表、慢性阻塞性肺疾病患者自我评估测试量表评分均明显降低,且观察组上述指标均明显优于对照组(P<0.05)。观察组与对照组不良反应发生率相当(13.33%比8.33%,P>0.05)。结论麻杏石甘汤加减联合经鼻高流量湿化氧疗治疗肺炎Ⅰ型呼吸衰竭的临床疗效良好,可改善患者的血气指标、肺通气功能及预后效果评分。Objective To investigate the clinical efficacy of modified Maxing Shigan Decoction combined with high-flow nasal cannula oxygen therapy(HFNC)in the treatment of pneumonia complicated with typeⅠrespiratory failure.Methods A total of 120 inpatients with pneumonia complicated with typeⅠrespiratory failure admitted to the hospital from January 2021 to May 2022 were selected and divided into the control group and the observation group by the computer-system random lottery method,with 60 patients in each group.The patients in the two groups were given the routine treatment and HFNC,on this basis,the patients in the observation group were given modified Maxing Shigan Decoction.Both groups were treated for three courses of treatment,with one week as a course of treatment.Results The total effective rate in the observation group was 91.67%,which was significantly higher than 75.00%in the control group(P<0.05).After treatment,the tidal volume(TV),vital capacity(VC),peak expiratory flow(PEF)and total lung capacity(TLC)in the two groups were significantly higher(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO2),arterial oxygen saturation(SaO2)and oxygenation index(OI)in the two groups were significantly higher,and the arterial partial pressure of carbon dioxide(PaCO2)in the two groups was significantly lower(P<0.05).After treatment,the scores of the Pneumonia Severity Index(PSI),Confusion,Urea,Respiratory rate,Blood pressure,Age 65(CURB-65)and Chronic Obstructive Pulmonary Disease Assessment Test(CAT)in the two groups were significantly lower(P<0.05).The above indexes in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(13.33%vs.8.33%,P>0.05).Conclusion Modified Maxing Shigan Decoction combined with HFNC in the treatment of pneumonia complicated with typeⅠrespiratory failure is effective,which can improve the blood gas index,pulmonary ventilation function and pro

关 键 词：肺炎 Ⅰ型呼吸衰竭 麻杏石甘汤 经鼻高流量湿化氧疗 血气指标 肺通气功能 临床疗效 预后 

分 类 号：R969.3[医药卫生—药理学] R563.8[医药卫生—药学]