不孕不育特征与夫妻双方高血压患病风险的关联研究  

Study on the association between infertility characteristics and therisk of hypertension in couples

作　　者：李梦蝶 汪宝琳 王晓瑞 杨浅慧 甘虹 唐颖 刘开永[1] 邵珊珊 陶芳标[1] LI Meng-die;WANG Bao-lin;WANG Xiao-rui;YANG Qian-hui;GAN Hong;TANG Ying;LIU Kai-yong;SHAO Shan-shan;TAO Fang-biao(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University/Key Laboratory of Population Health Across Life Cycle,Ministry of Education of the People’s Republic of China/National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract/Anhui Province Key Laboratory of Population Health and Aristogenics,Hefei,Anhui 230032,China;不详)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,出生人口健康教育部重点实验室,国家卫生健康委配子及生殖道异常研究重点实验室,人口健康与优生安徽省重点实验室,安徽合肥230032 [2]安徽医科大学护理学院,人口健康与优生安徽省重点实验室

出　　处：《现代预防医学》2023年第10期1748-1753,共6页Modern Preventive Medicine

基　　金：国家重点研发计划(2018YFC1004201);国家自然科学基金(82273638)。

摘　　要：目的了解不孕不育夫妇高血压患病现况,探讨不孕不育特征与两性高血压患病风险的关联。方法本研究依托不孕不育队列开展。不孕不育特征包括是否患不孕不育、不孕不育类型、原因及年限。采用多因素logistic回归模型,分性别分析不孕不育特征与高血压的关联。结果1312对不孕不育夫妇中,不孕症女性和不育症男性高血压患病率均显著高于同性别对照组(女:18.6%vs.13.2%;男:21.5%vs.14.3%)。女性不孕(OR=1.64,95%CI:1.13~2.38)、双方共同原因不孕症(OR=2.15,95%CI:1.11~4.15)、继发性不孕(OR=1.58,95%CI:1.17~2.13)和不孕年限≥3年(OR=1.96,95%CI:1.29~2.97)会显著增加女方高血压患病风险;男性不育(OR=1.79,95%CI:1.29~2.48)、双方共同原因不育症(OR=1.69,95%CI:1.12~2.56)、继发性不育(OR=1.52,95%CI:1.00~2.39)和不育年限≥3年(OR=1.97,95%CI:1.23~3.14)会显著增加男方高血压患病风险。结论确诊不孕不育、继发性不孕不育、双方共同原因不孕不育及长不孕不育年限是不孕不育夫妇患高血压的风险因素。Objective To examine the prevalence of hypertension in infertile couples and the association between infertility characteristics and the risk of hypertension in women and men.Methods This study was conducted based on the infertility cohort from Anhui Province.Infertility characteristics included the presence or absence of infertility,the type of infertility,the cause,and years of infertility.The association between infertility characteristics and hypertension was analyzed by sex using a multifactorial logistic regression model.Results Among the 1312 infertile couples,the prevalence of hypertension was significantly higher in both infertile women and infertile men than that in the same-sex controls(women:18.6%vs.13.2%;men:21.5%vs.14.3%).Female infertility(OR=1.64,95%CI:1.13-2.38),combined causes infertility(OR=2.15,95%CI:1.11-4.15),secondary infertility(OR=1.58,95%CI:1.17-2.13)and infertility lasts more than 3 years(OR=1.96,95%CI:1.29-2.97)would significantly increase the risk of women’s hypertension in the female partner;male infertility(OR=1.79,95%CI:1.29-2.48),combined causes infertility(OR=1.69,95%CI:1.12-2.56),secondary infertility(OR=1.52,95%CI:1.00-2.39)and infertility lasts more than 3 years(OR=1.97,95%CI:1.23-3.14)significantly increased the risk of men’s hypertension.Conclusion Diagnosed infertility,secondary infertility,combined causes of infertility,and long duration of infertility are risk factors for hypertension in infertile couples.

关 键 词：不孕不育夫妇 高血压 不孕不育特征 

分 类 号：R544.1[医药卫生—心血管疾病]