超声引导下微波消融治疗甲状腺良性结节的体积缩小率与随访时间的阈值效应分析  

Threshold effect analysis of volume reduction ratio and follow-up time of benign thyroid nodules treated with ultrasound-guided microwave ablation

作　　者：陈益豪 刘伟宗[1] 晋春春 徐晓红 贡雪灏[1] CHEN Yi-hao;LIU Wei-zong;JIN Chun-chun;XU Xiao-hong;GONG Xue-hao(Department of Ultrasound,Shenzhen Second People’s Hospital,Shenzhen Guangdong 518035,China;Department of Ultrasound,Affiliated Hospital of Guangdong Medical University,Zhanjiang Guangdong 524001,China)

机构地区：[1]深圳市第二人民医院超声科,广东深圳518035 [2]广东医科大学附属医院超声科,广东湛江524001

出　　处：《中国临床医学影像杂志》2023年第5期323-326,共4页Journal of China Clinic Medical Imaging

基　　金：深圳市医学重点学科建设经费(SZXK052)。

摘　　要：目的:分析超声引导下微波消融(MWA)治疗甲状腺良性结节(BTN)的体积缩小率(VRR)与随访时间的阈值效应。方法:回顾性分析2020年7月—2021年6月在我院接受超声引导下MWA治疗BTN的患者资料,以12月为随访终点,VRR≥50%为治疗有效并纳入本研究。使用广义相加模型分析VRR随时间的变化趋势,生成VRR-时间拟合曲线图,应用分段线性回归模型计算阈值。结果:185例患者共213个结节纳入本研究,VRR-时间拟合曲线图显示MWA治疗后结节逐渐缩小,VRR逐渐增加。VRR与随访时间为非线性关系,分析两者阈值效应显示折点即阈值为2.7月;VRR在2.7月内增长速度最快,每个月增长25.7%(P<0.001);在2.7月后仍继续增长,但速度趋于平缓,每个月增长0.8%(P=0.018)。结论:超声引导下MWA治疗BTN的VRR与随访时间是非线性关系,存在阈值效应。Objective:To analyze the threshold effect of volume reduction ratio(VRR)and follow-up time in benign thy-roid nodules(BTN)treated with ultrasound-guided microwave ablation(MWA).Methods:Patients with BTN who received ultra-sound-guided MWA treatment in our hospital from July 2020 to June 2021 were retrospectively analyzed,with 12 months as the follow-up endpoint,and VRR≥50%was considered effective for treatment and included in this study.The trend of VRR with time was analyzed using the generalized additive model to generate the VRR-time fitting curve,and the segmented linear regression model was used to calculate the threshold value.Results:A total of 213 nodules in 185 patients were included in this study,and the VRR-time fitting curve showed a gradual decrease in nodule volume and a gradual increase in VRR after MWA.The relationship between VRR and follow-up time was nonlinear,and analysis of the threshold effect demonstrated the threshold value of 2.7 months,with the most significant growth rate of 25.7%/month(P<0.001)within 2.7 months after MWA and continued to grow at a slower rate of 0.8%/month after 2.7 months(P=0.018).Conclusion:Ultrasound-guided MWA for BTN has a nonlinear relationship between VRR and follow-up time,and there is a threshold effect.

关 键 词：甲状腺结节 导管消融术 超声检查 

分 类 号：R581[医药卫生—内分泌] R445.1[医药卫生—内科学]