Chemiluminescent carbon nanodots for dynamic and guided antibacteria  

作　　者：Jiang-Fan Han Qing Lou Zhong-Zheng Ding Guang-Song Zheng Qing-Chao Ni Run-Wei Song Kai-Kai Liu Jin-Hao Zang Lin Dong Cheng-Long Shen Chong-Xin Shan 

机构地区：[1]Henan Key Laboratory of Diamond Optoelectronic Materials and Devices,Key Laboratory of Material Physics,Ministry of Education,School of Physics and Microelectronics,Zhengzhou University,Zhengzhou 450052,China

出　　处：《Light(Science & Applications)》2023年第5期915-927,共13页光（科学与应用)（英文版）

基　　金：the support of the National Natural Science Foundation of China(U2004168,12074348 and 11974317);the Natural Science Foundation of Henan Province(212300410078).

摘　　要：Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant bacteria.Imageguided therapy is one of the most promising strategies for efficiently and accurately curing bacterial infections.Herein,a chemiluminescence(CL)-dynamic/guided antibacteria(CDGA)with multiple reactive oxygen species(ROS)generation capacity and chemiexcited near-infrared emission has been designed for the precise theranostics of bacterial infection by employing near-infrared emissive carbon nanodots(CDs)and peroxalate as CL fuels.Mechanistically,hydrogen peroxide generated in the bacterial microenvironment can trigger the chemically initiated electron exchange between CDs and energy-riched intermediate originated from the oxidized peroxalate,enabling bacterial induced inflammation imaging.Meanwhile,type Ⅰ/Ⅱ photochemical ROS production and type Ⅲ ultrafast charge transfer from CDs under the self-illumination can inhibit the bacteria proliferation efficiently.The potential clinical utility of CDGA is further demonstrated in bacteria infected mice trauma model.The self-illuminating CDGA exhibits an excellent in vivo imaging quality in early detecting wound infections and internal inflammation caused by bacteria,and further are proven as efficient broad-spectrum antibacterial nanomedicines without drug-resistance,whose sterilizing rate is up to 99.99%.

关 键 词：DYNAMIC ILLUMINATION initiated 

分 类 号：O64[理学—物理化学]